DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and C14B9.2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_498775.2	Gene:	C14B9.2 / 176147	WormBaseID:	WBGene00015752	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	183/494 - (37%)
Similarity:	269/494 - (54%)	Gaps:	46/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEG 91
            |.|:..|.:||...|::||.||||||||||||||.|||||.||||:|..:.|.:||.|||||:|.
Worm   147 EEVVTLTTENFDDFISNNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEK 211

  Fly    92 ELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIA 156
            :|..:|.|.||||:|..|:|...:|:|.|:||.||.::|.::.|.||.|..:.|.|:|:..:::.
Worm   212 DLGTKYGVSGYPTMKIIRNGRRFDYNGPREAAGIIKYMTDQSKPAAKKLPKLKDVERFMSKDDVT 276

  Fly   157 IIGFFKDLESEEAKTFTKVANAL-DSF-VFGVSSNADVIAKYEAKDNGVVLFKP------FDDKK 213
            |||||...:|...:.|:..|..| :.| ..|.:|:.....|::||.|.:::|.|      |:.|.
Worm   277 IIGFFATEDSTAFEAFSDSAEMLREEFKTMGHTSDPAAFKKWDAKPNDIIIFYPSLFHSKFEPKS 341

  Fly   214 SVF-EGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLL-------FFVS-REGGHIE 269
            ..: :.....|:|..|.:..|.||:.....::|:..:   .|..|:       |.|. |||.  |
Worm   342 RTYNKAAATSEDLLAFFREHSAPLVGKMTKKNAATRY---TKKPLVVVYYNADFSVQYREGS--E 401

  Fly   270 KYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDL 334
            .:...:..||:||:.|.....: :|||:..:..|..|:....:.. .::....|..||....|:.
Worm   402 YWRSKVLNIAQKYQKDKYKFAV-ADEEEFAKELEELGLGDSGLEH-NVVVFGYDGKKYPMNPDEF 464

  Fly   335 SA---ETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPW 396
            ..   |.:|||:|:...||.|.|:.|...|:| ||.|||.:|.|||:.:..|:||.||:||||||
Worm   465 DGELDENLEAFMKQISSGKAKAHVKSAPAPKD-DKGPVKTVVGSNFDKIVNDESKDVLIEFYAPW 528

  Fly   397 CGHCKQLAPIYDQLAEKYKDNE-DIVIAKMDSTANELES-IKISSFPTIKYFRKEDNK--VIDFN 457
            |||||.....|.:||:..|..: ::|:||||:|.|:..| ..:..|||| ||.....|  .|.::
Worm   529 CGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDAPSQFAVEGFPTI-YFAPAGKKSEPIKYS 592

  Fly   458 LDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDEL 496
            .:|.|:|..||:..:|             .:...|||||
Worm   593 GNRDLEDLKKFMTKHG-------------VKSFQKKDEL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	177/470 (38%)
		pdi_dom	33..133	CDD:273454	57/99 (58%)
		PDI_b_family	137..231	CDD:239279	29/102 (28%)
		PDI_b'_family	244..347	CDD:239280	28/113 (25%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	47/104 (45%)
C14B9.2	NP_498775.2	pdi_dom	41..138	CDD:273454
		ER_PDI_fam	147..616	CDD:273457	179/490 (37%)
		pdi_dom	152..253	CDD:273454	57/100 (57%)
		Thioredoxin_like	256..361	CDD:294274	29/104 (28%)
		PDI_b'_ERp72_ERp57	366..476	CDD:239371	26/116 (22%)
		PDI_a_PDI_a'_C	500..604	CDD:239293	47/104 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860