DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and pdi-1

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_497746.1	Gene:	pdi-1 / 175472	WormBaseID:	WBGene00003962	Length:	485	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	205/492 - (41%)
Similarity:	307/492 - (62%)	Gaps:	13/492 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPE 65
            |...:..:||    :.||..|.|...|.|||.|..||::.|..||||||:||||||.|||:|||:
Worm     1 MSLSVSFIFL----LVASIGAVVADSENVLVLTESNFEETINGNEFVLVKFYAPWCVHCKSLAPK 61

  Fly    66 YAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVT 130
            |.:||..|.|:.|.|||||||||....||.::.||||||:.:|:||.|.:|:|||..|.|:.||.
Worm    62 YDEAADLLKEEGSDIKLAKVDATENQALASKFEVRGYPTILYFKSGKPTKYTGGRATAQIVDWVK 126

  Fly   131 KKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAK 195
            ||:||....:.||...|:......:.::|:|||.:|:.|..:.:||:::|...|.|:.:|:|.|.
Worm   127 KKSGPTVTTVESVEQLEELKGKTRVVVLGYFKDAKSDAATIYNEVADSVDDAFFAVAGSAEVAAA 191

  Fly   196 YEAKDNGVVLFKPFDD---KKSVFEGEL-NEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
            ....::||.|.:...|   ..::.|.|: |...||::.....|..:.:|.||||.:|.||.:|..
Worm   192 ASLNEDGVALIRTDGDDSETSTIAEAEITNTIALKQWLHAYKLSAVTEFTHESAQEIVGGDLKKF 256

  Fly   257 LLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLE 321
            ....:.:.....::.:....|:|||:|..|:||.:..|.|::.||.||.|::.:..|..|::.|.
Worm   257 HFLIIRKSDSSFDETIAKFTEVAKKFRAKIVFVLLDVDVEENARILEFLGVDAKNTPANRIVSLA 321

  Fly   322 EDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSK 386
            :.:.|:||:    ..|..|||...:|:||..|.|.:|:|||||:..||||||:|||..:|||::|
Worm   322 DQVEKFKPQ----EGEDFEAFTNSYLEGKSAQDLKAQDLPEDWNALPVKVLVASNFNEIALDETK 382

  Fly   387 SVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDN 451
            :|.|:||||||||||||.|::|:|||||:.|.::||||:|:|.|||..:|::||||:|.:....:
Worm   383 TVFVKFYAPWCGHCKQLVPVWDELAEKYESNPNVVIAKLDATLNELADVKVNSFPTLKLWPAGSS 447

  Fly   452 KVIDFNLDRTLDDFVKFLDA-NGEVADSEPVEETEEE 487
            ..:|::.||.|:.|.:|::. .|..::||...:..||
Worm   448 TPVDYDGDRNLEKFEEFVNKYAGSASESETASQDHEE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	193/451 (43%)
		pdi_dom	33..133	CDD:273454	58/99 (59%)
		PDI_b_family	137..231	CDD:239279	26/97 (27%)
		PDI_b'_family	244..347	CDD:239280	31/102 (30%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	55/100 (55%)
pdi-1	NP_497746.1	ER_PDI_fam	23..474	CDD:273457	194/454 (43%)
		pdi_dom	28..129	CDD:273454	58/100 (58%)
		PDI_b_family	133..211	CDD:239279	21/77 (27%)
		PDI_b'_family	<263..343	CDD:239280	25/83 (30%)
		PDI_a_PDI_a'_C	364..465	CDD:239293	55/100 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1096
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.880