DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pdi and Pdia3

DIOPT Version :9

Sequence 1:NP_001287070.1 Gene:Pdi / 39651 FlyBaseID:FBgn0286818 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_031978.2 Gene:Pdia3 / 14827 MGIID:95834 Length:505 Species:Mus musculus


Alignment Length:524 Identity:175/524 - (33%)
Similarity:269/524 - (51%) Gaps:76/524 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 ALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADN---EFVLVEFYAPWCGHCKALAPEYAK 68
            ||.||::.:||:::        ||..|.:||:..::|.   ..:||||:||||||||.|||||..
Mouse    13 ALLLASARLAAASD--------VLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69

  Fly    69 AAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV-EYSGGRQAADIIAWVTKK 132
            ||.:|   :..:.|||||.|.......:|.|.||||||.||.|... .|.|.|.|..|::.:.|:
Mouse    70 AATRL---KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131

  Fly   133 TGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVA-NALDSFVFGVSSNADVIAKY 196
            .||.:..|.:..:.::|:.|.:.:::|||:||.|:....|.|.| |..|::.|..::...::.:|
Mouse   132 AGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEY 196

  Fly   197 EAKDNGVVLFKP------FDDKKSVF-EGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIK 254
            :....|:.:|:|      |:||...: |.::....:|||.|.....|......::...|.|..: 
Mouse   197 DDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDL- 260

  Fly   255 SHLLFFVSREGGHIEKYVDPLKE---------------IAKKYRD---DILFVTISSDEEDHTRI 301
                         :..|.|...|               :|||:.|   .:.|...|.....|.  
Mouse   261 -------------LTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHE-- 310

  Fly   302 FEFFGMNKE--EVP--TIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPE 362
            ...||:...  |||  .||..|.|:.:.:   |......:.:|.||:::.||.||::|.|:.:||
Mouse   311 LSDFGLESTTGEVPVVAIRTAKGEKFVMQ---EEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPE 372

  Fly   363 DWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDS 427
            . ::.||||:|:.||:.:..::.|.||:|||||||||||.|.|.|.:|.||...:.:|||||||:
Mouse   373 S-NEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDA 436

  Fly   428 TANELES-IKISSFPTIKYFRKEDNKVI--DFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEE 489
            |||::.| .::..|||| ||...:.|:.  .:...|.|:||:.:|...   |.:.|:    .:||
Mouse   437 TANDVPSPYEVKGFPTI-YFSPANKKLTPKKYEGGRELNDFISYLQRE---ATNPPI----IQEE 493

  Fly   490 APKK 493
            .|||
Mouse   494 KPKK 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PdiNP_001287070.1 ER_PDI_fam 27..474 CDD:273457 162/483 (34%)
pdi_dom 33..133 CDD:273454 47/103 (46%)
PDI_b_family 137..231 CDD:239279 26/101 (26%)
PDI_b'_family 244..347 CDD:239280 25/124 (20%)
PDI_a_PDI_a'_C 368..469 CDD:239293 49/103 (48%)
Pdia3NP_031978.2 ER_PDI_fam 26..487 CDD:273457 163/495 (33%)
Thioredoxin 27..131 CDD:278513 48/106 (45%)
PDI_b_ERp57 135..240 CDD:239367 27/104 (26%)
PDI_b'_ERp72_ERp57 244..357 CDD:239371 25/131 (19%)
PDI_a_PDI_a'_C 377..480 CDD:239293 49/103 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..505 7/18 (39%)
Prevents secretion from ER. /evidence=ECO:0000250 502..505
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846787
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0190
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53639
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000292
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100478
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2224
SonicParanoid 1 1.000 - - X241
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.680

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