DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Pdia4

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001355685.1	Gene:	Pdia4 / 12304	MGIID:	104864	Length:	699	Species:	Mus musculus

Alignment Length:	572	Identity:	170/572 - (29%)
Similarity:	269/572 - (47%)	Gaps:	141/572 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AASYVAASAEAEV--KVE-----------EGVLVATVDNFKQLIADNEFVLVEFYAP-------- 54
            |..|..:..:.|:  ||.           |..|..|.|||..::.:.:.:|||||||
Mouse   144 AVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLSLTKDNFDDVVNNADIILVEFYAPWTVALLLF 208

  Fly    55 --------------------------------------------------WCGHCKALAPEYAKA 69
                                                              ||||||.|||||.||
Mouse   209 SLSFYQFAVLLSTHTGLLDVNANDKSLMFQQFSVPVGPVLSFSPRRHSKIWCGHCKKLAPEYEKA 273

  Fly    70 AQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTG 134
            |::|:::..||.|||||||.:.:||:::.|.||||||.||.|.|.:|:|.|:...|:.::.:::|
Mouse   274 AKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDYMIEQSG 338

  Fly   135 PPAKDLTSVADAEQFLKD-NEIAIIGFFKDLESEEAKTFTKVANAL-DSFVFGVSSNADVIAKYE 197
            ||:|::.::...::|||| :::.|||.|:.........:...||.| :.:.|..:.:.: |||:.
Mouse   339 PPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGDPAYLQYQDAANNLREDYKFHHTFSPE-IAKFL 402

  Fly   198 AKDNG-VVLFKP--FDDKKSV------FEGELNEENLKKFAQVQSLPLI---------------- 237
            ....| :||..|  |..|...      .:|......:|.:....:|||:
Mouse   403 KVSLGKLVLTHPEKFQSKYEPRFHVMDVQGSTEASAIKDYVVKHALPLVGHRKTSNDAKRYSKRP 467

  Fly   238 -------VD--FNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISS 293
                   ||  |::.:|::.:...:                      .|:||.:.:   :....:
Mouse   468 LVVVYYSVDFSFDYRAATQFWRNKV----------------------LEVAKDFPE---YTFAIA 507

  Fly   294 DEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQ 358
            ||||:....:..|:: |....:....|:|...|:..|.::..::|:..|:..|..||||..:.||
Mouse   508 DEEDYATEVKDLGLS-ESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQ 571

  Fly   359 ELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIA 423
            .:|:: :|.||||:|...|:::.:|..|.||:|||||||||||||.|||..|.:|||..:|:|||
Mouse   572 PVPKN-NKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIA 635

  Fly   424 KMDSTANEL--ESIKISSFPTIKYFRKEDNKVIDFNLD---RTLDDFVKFLD 470
            |||:|||::  :..|:..|||| ||....:|......:   |.|:...||:|
Mouse   636 KMDATANDITNDQYKVEGFPTI-YFAPSGDKKNPIKFEGGNRDLEHLSKFID 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	165/543 (30%)
		pdi_dom	33..133	CDD:273454	52/157 (33%)
		PDI_b_family	137..231	CDD:239279	24/104 (23%)
		PDI_b'_family	244..347	CDD:239280	16/102 (16%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	51/105 (49%)
Pdia4	NP_001355685.1	pdi_dom	63..164	CDD:273454	5/19 (26%)
Pdia4	NP_001355685.1	ER_PDI_fam	173..691	CDD:273457	165/543 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860