DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Pdia4

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_446301.2	Gene:	Pdia4 / 116598	RGDID:	619835	Length:	643	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	164/514 - (31%)
Similarity:	272/514 - (52%)	Gaps:	83/514 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AASYVAASAEAEV--KVE-----------EGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKAL 62
            |..|..:..:.|:  ||.           |..|..|.:||..::.:.:.:|||||||||||||.|
  Rat   146 AVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLTLTKENFDDVVNNADIILVEFYAPWCGHCKKL 210

  Fly    63 APEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIA 127
            ||||.|||::|:::..||.|||||||.:.:||:::.|.||||||.||.|.|.:|:|.|:...|:.
  Rat   211 APEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVD 275

  Fly   128 WVTKKTGPPAKDLTSVADAEQFLKD-NEIAIIGFFKDLESEEAKTFTKVANAL-DSFVFGVSSNA 190
            ::.:::|||:|::.::...::|||| :::.|:|.|:.:.......:...||.| :.:.|..:.:.
  Rat   276 YMVEQSGPPSKEILTLKQVQEFLKDGDDVVILGVFQGVGDPGYLQYQDAANTLREDYKFHHTFST 340

  Fly   191 DVIAKYEAKDNG-VVLFKP------FDDKKSVF--EGELNEENLKKFAQVQSLPLI--------- 237
            : |||:.....| :||.:|      ::.:..|.  :|......:|.:....:|||:
  Rat   341 E-IAKFLKVSLGKLVLMQPEKFQSKYEPRMHVMDVQGSTEASAIKDYVVKHALPLVGHRKTSNDA 404

  Fly   238 --------------VD--FNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDI 286
                          ||  |::.:|::.:...:                      .|:||.:.:
  Rat   405 KRYSKRPLVVVYYSVDFSFDYRTATQFWRNKV----------------------LEVAKDFPE-- 445

  Fly   287 LFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKL 351
             :....:||||:....:..|:: |....:....|:|...|:..|.::..::.:..|:..|..|||
  Rat   446 -YTFAIADEEDYATEVKDLGLS-ESGEDVNAAILDESGKKFAMEPEEFDSDALREFVMAFKKGKL 508

  Fly   352 KQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKD 416
            |..:.||.:|:: :|.||:|:|...|:::.:|..|.||:|||||||||||||.|:|..|.:|||.
  Rat   509 KPVIKSQPVPKN-NKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSLGKKYKG 572

  Fly   417 NEDIVIAKMDSTANEL--ESIKISSFPTIKYFRKEDNKVIDFNLD---RTLDDFVKFLD 470
            .:|:||||||:|||::  :..|:..|||| ||....:|......:   |.|:...||:|
  Rat   573 QKDLVIAKMDATANDITNDRYKVEGFPTI-YFAPSGDKKNPIKFEGGNRDLEHLSKFID 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	159/485 (33%)
		pdi_dom	33..133	CDD:273454	51/99 (52%)
		PDI_b_family	137..231	CDD:239279	22/104 (21%)
		PDI_b'_family	244..347	CDD:239280	15/102 (15%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	49/105 (47%)
Pdia4	NP_446301.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..58
		pdi_dom	65..166	CDD:273454	5/19 (26%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	89..92
		ER_PDI_fam	175..635	CDD:273457	159/485 (33%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	553..556		2/2 (100%)
		Prevents secretion from ER	640..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830