Protein Alignment Pdi and Txndc5

DIOPT Version :9

• Sequence 1: NP_001287070.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_663342.3
• Gene: Txndc5 / 105245
• MGIID: 2145316
• Length: 417
• Species: Mus musculus
• Alignment Length: 506
• Identity: 120/506 - (23%)
• Similarity: 190/506 - (37%)
• Gaps: 154/506 - (30%)

  Fly     4 LICALFLAASYVAASAEAEVKVEEGV-------LVATVDNFKQLI-ADNEFVLVEFYAPWCGHCK 60
            |...|.|..:...|.|: ||:.:.||       .:.|.|.|...| :...||:  |:|||||||:
Mouse    18 LATLLLLLGARKGARAQ-EVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVM--FFAPWCGHCQ 79

  Fly    61 ALAPEYAKAAQQLAEK-----ESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG-SPVEYSGG 119
            .|.|.:    ..|.:|     ::.:.:||||.|.:.::.....||||||||||:.| ..|:|.|.
Mouse    80 RLQPTW----NDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGP 140

  Fly   120 RQAADIIAWVTK------KTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTK---- 174
            |....:..|:.:      .|..|..:.....:.:|.|  .|::...|  :|...:...|.|
Mouse   141 RDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGL--YELSANNF--ELHVSQGNHFIKFFAP 201

  Fly   175 -------VANALDSFVFGVSSNADV-IAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQV 231
                   :|...:....|:..:..| |.|.:...:..|..:                     .||
Mouse   202 WCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSE---------------------HQV 245

  Fly   232 QSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEE 296
            :..|.                    ||:|  |:|..:::|
Mouse   246 RGYPT--------------------LLWF--RDGKKVDQY------------------------- 263

  Fly   297 DHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELP 361
                      ..|.::.::|      |..:.:.:..:.:.||:|                ..|.|
Mouse   264 ----------KGKRDLESLR------DYVQSQLQGSEAAPETVE----------------PSEAP 296

  Fly   362 -----EDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEK-YKDNEDI 420
                 ...||..|..|...:||...  ......|:||||||||||.|||.:::|::| :....|:
Mouse   297 VMAAEPTGDKGTVLALTEKSFEDTI--AQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDV 359

  Fly   421 VIAKMDSTA--NELESIKISSFPTIKYFRKEDNKVIDFNLDRTLDDFVKFL 469
            .||::|.||  |......:..:||:..||..: ||.:.|..|.||....|:
Mouse   360 TIAEVDCTAERNVCSKYSVRGYPTLLLFRGGE-KVGEHNGGRDLDSLHSFV 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	113/483 (23%)
		pdi_dom	33..133	CDD:273454	39/112 (35%)
		PDI_b_family	137..231	CDD:239279	13/105 (12%)
		PDI_b'_family	244..347	CDD:239280	12/102 (12%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	37/103 (36%)
Txndc5	NP_663342.3	PDI_a_ERp46	47..150	CDD:239303	38/108 (35%)
		ER_PDI_fam	52..417	CDD:273457	111/471 (24%)
		PDI_a_ERp46	176..276	CDD:239303	24/187 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..302		5/36 (14%)
		PDI_a_ERp46	308..409	CDD:239303	37/103 (36%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	414..417

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910