Protein Alignment Cep135 and CEP135

DIOPT Version :9

• Sequence 1: NP_001189108.1
• Gene: Cep135 / 39647
• FlyBaseID: FBgn0036480
• Length: 1065
• Species: Drosophila melanogaster
• Sequence 2: NP_079285.2
• Gene: CEP135 / 9662
• HGNCID: 29086
• Length: 1140
• Species: Homo sapiens
• Alignment Length: 1173
• Identity: 278/1173 - (23%)
• Similarity: 506/1173 - (43%)
• Gaps: 204/1173 - (17%)

  Fly    10 DLRCKLDIMGFTQTLPVLAIPLVQAVFGDLIKTTECLRDTKKKVAELLEEKTCWELGVEPYKCDN 74
            ::|.:||.:|:.|||.|..:|||:.:|.||:.|||.||.:|....:..:|...::..:||||.:|
Human    11 NIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLEN 75

  Fly    75 SRLLAECNELHLQFLRDRED------------------------------YELRLCESERKIRNL 109
            :||..|.|||:|:.::.||.                              ::|:|.|.|.|.:|.
Human    76 ARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNE 140

  Fly   110 ELDKQHLQSHNDGLQRQLDALLTKQMVSSVTNKKATAGIGRQTKKPFITTVRSGIAMPTTLGTSS 174
            .:  |.||..|      |.|     :|.:...||.:....||         |..|..|......|
Human   141 RI--QQLQEKN------LHA-----VVQTPGGKKRSIAFRRQ---------RMQIDEPVPPSEVS 183

  Fly   175 SALKCTKCNAGVFQKTTTTTKDGVTVTQTSGQE---ELDKMQNDLTAAGEQLEFFKRKVEARNRE 236
            |        ..|.|.......|.:.|.....||   |:.::|..|......:..:.:::|.|.||
Human   184 S--------YPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELRERE 240

  Fly   237 IRRLNDMLAGGRPLAALAKDCCYKD----VGALSQDIDLLQREKSDLMMQVREFQDKMHDAMQRA 297
            |.||:..|.|||....|:.:...|.    :..|:..:|.||:...||..::||..:.........
Human   241 IERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEV 305

  Fly   298 --LSSEEDKI--------KLQTQLEELKEAALQVEQ----QANAEIDAKESELR---------QL 339
              ||::.:|:        :|..|||..||..|:...    :|..||..|.||::         ||
Human   306 VNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQL 370

  Fly   340 QLELKKKGKDHRLTGGF---ASNQSDKHNLNERLNLLTRREEELQATNEKHKKKIQKMQAKILEL 401
            :|.|.:|.|: ||:...   :..::..|.|.:....|:::.|....|..:...::::|:     |
Human   371 ELNLCQKEKE-RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMR-----L 429

  Fly   402 QKELKDQNKHSNVTLDEEKIRLSSERDFFQKEYLRLM----------SKTGSESEIAF------- 449
            :..:|.::: |...||.....:..|||:::||..||.          |.:..|....|
Human   430 EHGIKRRDR-SPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGD 493

  Fly   450 ----LHAQIKSKDE-----------------ELKALRSE------LFHGGKQQFSPQKSVQYETL 487
                :|...:.:||                 .:|.|.:|      |::..:::.|..:....:|.
Human   494 YNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTT 558

  Fly   488 PPPTASSITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHADELQA 552
            .|....|:                  :|:|::.|.::|.|:..|::.||||     ..|.:|:..
Human   559 APHNIVSL------------------MEKEKELALSDLRRIMAEKEALREK-----LEHIEEVSL 600

  Fly   553 LRLRNEELNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMR-------QRVASMQTEIDQLK 610
              ....||...:..:...|.:|.|.:...::.::::||.:..:.       |:.:.:..:....|
Human   601 --FGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQK 663

  Fly   611 TENDQITMLNDQNERIIADYQSKLLVAERQRQSADVRASTLDSSRESNRSEVTQLRMDLGALRQT 675
            ||.:.:.::|:|.:|.:.|||.:|.:...:.:||..:...|:...:....::|....:...:::|
Human   664 TEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKT 728

  Fly   676 YISLEHEKDTLLHQLDTKTERVYKLEYELKDCKEKRNA-LEQNVKDLEDQLRKLANRNRQRDSEL 739
            ...::.|||.|...:|.|||::..|:..|.: |||..| ::..:.:.|..:.:|......||.|:
Human   729 IGVIDKEKDFLQETVDEKTEKIANLQENLAN-KEKAVAQMKIMISECESSVNQLKETLVNRDREI 792

  Fly   740 TETSTESKTLRQQIVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSELQVANMKQQLHK 804
            .....:.....:::..:..||:.|..|||||.|.|:....|.:.:..:|..:..:...||.::||
Human   793 NSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHK 857

  Fly   805 YVQEVKKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQATLEGNNQSLECEAVEFRRQICELEC 869
            |:.||.:.|.|:..      ||||..|:||::..|.......|......|.|:...|.::..::.
Human   858 YITEVSRWESLMAA------KEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDT 916

  Fly   870 EVHSLKEQLQLRQ-------CALHDMEVQLTAARASVRCLERELENARDDIRVQKVDLEARKELC 927
            |...|:|:::|.:       .|.|..|.|:::...::..||.||.:..|:......||.:.:|||
Human   917 ERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELC 981

  Fly   928 DKLDVERSKLNAELNDVNEIRKKLEKQCEKLRDE---LQQSLAINQVTNETTDLMLGRLHNDQQH 989
            .|||..:..:..:||..|...:::..:.|.::.|   |::.|:..:.|.:..:.:|....:.:.|
Human   982 IKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFH 1046

  Fly   990 QEDDDIRSKHEMDRLQRQLQQTLDQLQEERV--RCRHHEELAEKWEQQVRD---LRRNLADDRYN 1049
            ..    .:.||.|...:.|::.| .|.|.::  :.|.:..|..|..|...|   |:|.::.:||.
Human  1047 SH----LTSHEKDTEIQLLKEKL-TLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYE 1106

  Fly  1050 QAR 1052
            :.|
Human  1107 RER 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	195/854 (23%)
		DUF342	<302..421	CDD:302792	33/142 (23%)
CEP135	NP_079285.2	SMC_N	199..1038	CDD:330553	199/877 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1140

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1893
eggNOG	1	0.900	-	-		E1_28KKT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45709
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3054
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139407at2759
OrthoFinder	1	1.000	-	-		FOG0007527
OrthoInspector	1	1.000	-	-		otm40703
orthoMCL	1	0.900	-	-		OOG6_104787
Panther	1	1.100	-	-	LDO	PTHR23159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5276
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860