Protein Alignment Cep135 and SPC110

DIOPT Version :10

• Sequence 1: NP_001189108.1
• Gene: Cep135 / 39647
• FlyBaseID: FBgn0036480
• Length: 1065
• Species: Drosophila melanogaster
• Sequence 2: NP_010643.3
• Gene: SPC110 / 851957
• SGDID: S000002764
• Length: 944
• Species: Saccharomyces cerevisiae
• Alignment Length: 929
• Identity: 197/929 - (21%)
• Similarity: 395/929 - (42%)
• Gaps: 250/929 - (26%)

  Fly   194 TKDGVTVTQTSGQEELDKMQNDLTAAGEQLEFFKRKVEARNREIRRLNDMLAGGRPLAALAK-DC 257
            :|...|.||.....::....|     |::.|     ...:.|:.|.::|.:...|..:..:: |.
Yeast    25 SKRNTTQTQVVSPTKVPNANN-----GDENE-----GPVKKRQRRSIDDTIDSTRLFSEASQFDD 79

  Fly   258 CYKDVGA------LSQDID------LLQREKSDLMM-------QVREFQDKMHDAMQRALSSEED 303
            .:.::.|      .|.::|      |:...|.|:.|       :|||.|.| .:...|||   |.
Yeast    80 SFPEIKANIPPSPRSGNVDKSRKRNLIDDLKKDVPMSQPLKEQEVREHQMK-KERFDRAL---ES 140

  Fly   304 KIKLQTQLEELKEAALQVEQQANAEIDAKE---SELRQLQLELKKKGKDHRLT-GGFASNQSDKH 364
            |:..:..:           ..||::|..||   :|::.|:.|:|:..|:...| ..:.:.:.:..
Yeast   141 KLLGKRHI-----------TYANSDISNKELYINEIKSLKHEIKELRKEKNDTLNNYDTLEEETD 194

  Fly   365 NLNERLNLLTRREEELQATNE-KHKKKI----------QKMQAKILELQKELKDQNKHSNVTLDE 418
            :|..||..|   |:||.|.|: .:.:|:          ::|:.|:.||:::||        |:.:
Yeast   195 DLKNRLQAL---EKELDAKNKIVNSRKVDDHSGCIEEREQMERKLAELERKLK--------TVKD 248

  Fly   419 EKIRLSSERDFFQKEYLRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHGGKQQFSPQKSVQ 483
            :.:.|.:..|.   :.|:|                 :||::|||.|.:||
Yeast   249 QVLELENNSDV---QSLKL-----------------RSKEDELKNLMNEL--------------- 278

  Fly   484 YETLPPPTASSITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREK--QLSTVQLH 546
                         :.:.||.            .|:|   |:||   .:::.||::  :|:.:::.
Yeast   279 -------------NELKSNA------------EEKD---TQLE---FKKNELRKRTNELNELKIK 312

  Fly   547 ADE--LQALRLRNE--ELNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMRQ---------- 597
            :||  ||..:.:||  .|.|.|.::|....|..|.....|..|.:||..:.::.:
Yeast   313 SDEMDLQLKQKQNESKRLKDELNELETKFSENGSQSSAKENELKMLKNKIAELEEEISTKNSQLI 377

  Fly   598 ----RVASMQTEIDQLKTE-NDQITMLNDQNERIIA---DYQSKLLVAERQRQSADVRASTLDSS 654
                ::||:..::.||::: |.:.:.|..:.|.:..   ..|..:.:|..:..|.|.|...|
Yeast   378 AKEGKLASLMAQLTQLESKLNQRDSQLGSREEELKKTNDKLQKDIRIAREETVSKDERIIDL--- 439

  Fly   655 RESNRSEVTQLRMDLGALRQTYISLEHEKDTLL-HQLDTKTERVYKLEYELKDCKEKRNALEQNV 718
                :.:|.||..||..:::|:    .|..|:. ::|::|.:.:..||.:||..:||.:.:|:.:
Yeast   440 ----QKKVKQLENDLFVIKKTH----SESKTITDNELESKDKLIKILENDLKVAQEKYSKMEKEL 496

  Fly   719 KDLEDQLRKLANRNRQRDSELTETSTESK--TLRQQIVALKASRDEAIAENRRLMDKLSDAQVEA 781
            |:            |:.:.:::|:..|.:  ||.::|..|       .|||.:|.:|:.|.....
Yeast   497 KE------------REFNYKISESKLEDEKTTLNEKISNL-------AAENSQLKNKIEDNSTAT 542

  Fly   782 RTLQKKLTDSELQVANMKQQLHKYVQEVKKAED------LLIQKVSSKFKEKERDDML---DQYH 837
            ..:::   :.|.|:.::::.:.:|.:..|.:||      :.|.:.|:|..||...|:.   :|..
Yeast   543 HHMKE---NYEKQLESLRKDIEEYKESAKDSEDKIEELKIRIAENSAKVSEKRSKDIKQKDEQIS 604

  Fly   838 CLTQGQATLEGNNQSLECEAVEFRRQICELECEVHSLKEQLQLRQCALHDMEVQLTAARASVRCL 902
            .|||.....|....||:.....:::...:|:.|..:::          ||:.:|:......:...
Yeast   605 DLTQNLKLQEDEISSLKSIIDRYKKDFNQLKSEQSNIQ----------HDLNLQILNLENKLIES 659

  Fly   903 ERELENARDDIRVQKVDLEARKELCDKLDVERSK-----------------LNAELNDVNEIRKK 950
            |.||::.||.   ||:::|..|...:.|.:|..:                 ||.:|:::::.:..
Yeast   660 EDELKSLRDS---QKIEIENWKRKYNNLSLENDRLLTEKESASDKEREISILNRKLDEMDKEKWN 721

  Fly   951 LEKQCEKLRDELQQSLAINQVTNETTDLMLGRLHNDQQ--HQEDDDIR-SKHEMDRLQRQLQQTL 1012
            |::..||.:.|||:.:..|.           ||..:::  ::..::|| .:.:|.|:::.....:
Yeast   722 LQESKEKYKRELQKVITAND-----------RLRREKEELNENSNNIRIMEDKMTRIKKNYLSEI 775

  Fly  1013 DQLQEERVRCRHHEELAEK 1031
            ..||||..|......|.|:
Yeast   776 TSLQEENRRLEERLILNER 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	DR0291	206..>346	CDD:441187	34/162 (21%)
		SMC_prok_B	286..1044	CDD:274008	175/817 (21%)
SPC110	NP_010643.3	SMC_prok_B	196..>793	CDD:274008	156/730 (21%)
		Spc110_C	893..944	CDD:375946