DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep135 and TSGA10

DIOPT Version :9

Sequence 1:	NP_001189108.1	Gene:	Cep135 / 39647	FlyBaseID:	FBgn0036480	Length:	1065	Species:	Drosophila melanogaster
Sequence 2:	XP_011510236.1	Gene:	TSGA10 / 80705	HGNCID:	14927	Length:	898	Species:	Homo sapiens

Alignment Length:	1095	Identity:	234/1095 - (21%)
Similarity:	425/1095 - (38%)	Gaps:	315/1095 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RDTKKKV--AELLEEKTCWELGVEPYKCDNSRLLAECNELHLQFLRDREDYELRLCESERKIRNL 109
            ||.:.:|  ||:..::..:.||....:.:|.:     |.|.|       :.|:|  ..:|.|..|
Human    14 RDPELQVEAAEVTTKEYDFGLGAPVSEAENYQ-----NTLQL-------EQEVR--NQDRFISTL 64

  Fly   110 ELDKQHLQSHNDGLQRQLDALL-TKQMVSSVTNKKATAGIGRQTKKPFITTVRSGIAMPTTLGTS 173
            :|..:.|:..|.||:..:..|| :|::|||..:..                            ||
Human    65 KLQIEDLKQTNHGLEEYVRKLLDSKEVVSSQVDDL----------------------------TS 101

  Fly   174 SSALKCTKCNAGVFQKTTTTTKDGVTVTQTSGQEELDKMQNDLTAAGEQLEFFKRKVEARNREIR 238
            .:...|               |:.:.:.|.:  |:|:|.:|.:             |::.|:|
Human   102 HNEHLC---------------KELIKIDQLA--EQLEKEKNFV-------------VDSANKE-- 134

  Fly   239 RLNDMLAGGRPLAALAKDCCYKDVGALSQDIDLLQREKSDLMMQVREFQDKMHDAMQRALSSEED 303
                                             |:..|.||:.|                  :.:
Human   135 ---------------------------------LEEAKIDLICQ------------------QNN 148

  Fly   304 KIKLQTQLEELKEAALQVEQQAN--------------AEIDAKESELRQLQLELKKKGKDHRLTG 354
            .|.|:..::.||...|..|:..|              |:.|..:||.:.|:..::.:.|..|...
Human   149 IIVLEDTIKRLKSIILDTEKAQNKSPSRLDSFVKTLEADKDHYKSEAQHLRKMMRSRSKSPRRPS 213

  Fly   355 GFASNQSDKHNLN-ERLNLLTRREEELQATNEKHKKKIQKMQAKILELQKELKDQNKHSNVTLDE 418
            ..|...    |.: |.|...||..|||:...||:::.:.::|..:
Human   214 PTARGA----NCDVELLKTTTRDREELKCMLEKYERHLAEIQGNV-------------------- 254

  Fly   419 EKIRLSSERDFFQKEYLRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHGGKQQFSPQKSVQ 483
             |: |.||||                 :|..|:.|.:   ||:..||.|:....|   ||:
Human   255 -KV-LKSERD-----------------KIFLLYEQAQ---EEITRLRREMMKSCK---SPK---- 290

  Fly   484 YETLPPPTASSITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHAD 548
                                |....|.:.|||.|||.|.|:|.|:..|||:|||: |...|..|.
Human   291 --------------------STTAHAILRRVETERDVAFTDLRRMTTERDSLRER-LKIAQETAF 334

  Fly   549 ELQALRLRNEELNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMRQRVASM-------QTEI 606
            ..:|      .|..|:.::|.....|:..|:...:|:.|:||.:..:.:.:.|:       ::|:
Human   335 NEKA------HLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESEL 393

  Fly   607 DQLKTENDQITMLNDQNERIIADYQSKLLVAERQRQSADVRASTLDSSRES-NRSEVTQLRMDLG 670
            .:.|.||:.:.:|.:..|:.::|.|..|...:.:.|....:...||...:: .|..:.| |.::.
Human   394 GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ-REEIS 457

  Fly   671 ALRQTYISLEHEKDTLLHQLDTKTERVYKLEYELKDCKEKRNALEQNVKDLEDQLRKLANRNRQR 735
            .|..|...|..||:.|...||.|:|.:..|...|. .|||      .:..:::.:.::...:||.
Human   458 ILGGTLNDLAKEKECLQACLDKKSENIASLGESLA-MKEK------TISGMKNIIAEMEQASRQC 515

  Fly   736 DSELTETSTESKTLRQQ-------IVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSEL 793
            ...|.....:...:|:|       :..:...||....:|..|.::.:.|:.|.:.|.|||.|:..
Human   516 TEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHN 580

  Fly   794 QVANMKQQLHKYVQEVKKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQAT-------LEGNNQ 851
            ::.::||::.....||.|.:::|      |.:|.|...|::|.....:....       .|.:|.
Human   581 ELNDIKQKVQDTNLEVNKLKNIL------KSEESENRQMMEQLRKANEDAENWENKARQSEADNN 639

  Fly   852 SLECEAVEFRRQICELECEVHSLKEQLQLRQCALHDMEVQLTAARASVRCLERELENARDDIRVQ 916
            :|:.|.:....:...|:.:|.||..:::....|....:.|::....||..:|.||:.    ::.:
Human   640 TLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQK----VQFE 700

  Fly   917 KV----DLEARKELCDKLDVERSKLNAEL-----------NDVNEIRKKLE-------------K 953
            ||    ||.:.:|||.|||..:..||.:|           |:::....::|             :
Human   701 KVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQ 765

  Fly   954 QCEKL----RD-ELQQSLAINQVTNETTDLMLGRLH-----NDQQHQEDDDIRSKHEMDRLQRQL 1008
            ..|.|    || |.|..:|:.:   :.:::.|.:.|     |....|..|..:.::.:.:|:..|
Human   766 NLEALLVANRDKEYQSQIALQE---KESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADL 827

  Fly  1009 QQTLDQLQEERVRCRHHEELAEKWEQQVRDLRR-NLADDRYNQARTREVSPRVPS 1062
            ..|..||..||.          :.|:.|::||| |.:.:.|:.:.|.:.:.:..|
Human   828 DITKRQLGTERF----------ERERAVQELRRQNYSSNAYHMSSTMKPNTKCHS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	179/829 (22%)
Cep135	NP_001189108.1	DUF342	<302..421	CDD:302792	26/133 (20%)
TSGA10	XP_011510236.1	FlaC_arch	50..96	CDD:283120	17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1893
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3054
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40703
orthoMCL	1	0.900	-	-		OOG6_104787
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.930