DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cep135 and tsga10

DIOPT Version :9

Sequence 1:	NP_001189108.1	Gene:	Cep135 / 39647	FlyBaseID:	FBgn0036480	Length:	1065	Species:	Drosophila melanogaster
Sequence 2:	XP_005160173.1	Gene:	tsga10 / 768146	ZFINID:	ZDB-GENE-061013-482	Length:	717	Species:	Danio rerio

Alignment Length:	705	Identity:	165/705 - (23%)
Similarity:	319/705 - (45%)	Gaps:	106/705 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 NLNERLNLLTRREEELQATNEKHKKKIQKMQAKILELQKELKDQNKHSNVTLDEEKIRLSSERDF 429
            :.:..|..:.|..:|||...:||::.:.:.||.:                     |: |::|||.
Zfish    30 SFDSELMRVLRERDELQNMLDKHERHLSETQANV---------------------KV-LTAERDK 72

  Fly   430 FQKEYLRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHGGKQQFSPQKSVQYETLPPPTASS 494
            .:..|.:      ::.|||.|..::         ::|:...|.|                  :.|
Zfish    73 TRMHYQQ------AQEEIAALRREV---------MKSKAARGAK------------------SCS 104

  Fly   495 ITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHADELQALRLRNEE 559
            :|:          |:.:.|||.|||.|.::|.|:..|||:|||:...:.:....|...|....|:
Zfish   105 VTA----------QSILKRVETERDEAISDLNRMTTERDSLRERLKISQETSISERAHLEQTLED 159

  Fly   560 LNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMRQRVASMQTEIDQLKTENDQITMLNDQNE 624
            |...:..:|::..|..........|::.|:|::..:.:::::.:.|:.:.:.|...:.:.|:|.|
Zfish   160 LQAAVLTLEQERGEQKCRHAQMRENMMGLEEEVHNLSRKLSASEEELIRCRNECCSLRLSNNQME 224

  Fly   625 RIIADYQSKLLVAERQRQSADVRASTLDSSRESNRSEVTQLRMDLGALRQTYISLEHEKDTLLHQ 689
            ..:::.|.:|.....:.|:|..|..|||...:|...:||.||.:|...|.|...|:.:::||..|
Zfish   225 SSLSENQRRLTNRIGELQNAQERNKTLDEMNDSLVRQVTVLREELNTQRATISQLDQQRNTLQEQ 289

  Fly   690 LDTKTERVYKLEYELKDCKEKRNALEQNVKDLEDQLRKLANRNRQ-------RDSELTETSTESK 747
            ::.|::.:....::|.:.::...:|:...:|||..|..|.:.:|.       ::.||.....:..
Zfish   290 MEKKSDLINTANHQLDENEKTIRSLKLRAEDLETTLIVLCSPSRALRDTISGKERELDVLKRKLS 354

  Fly   748 TLRQQIVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSELQVANMKQQLHKYVQEVKKA 812
            ...:::..|...:|||..||.:|.|.|..|..|.:||:.||.::.|::.::::::..::.::.:.
Zfish   355 DSEKEMDTLMKVKDEASQENGQLRDDLDRAHQENQTLKFKLDEANLEIEDLQKKVQDHIADISRT 419

  Fly   813 EDLLIQKVSSKFKE-KERDDMLDQYHCLTQGQATLEGNNQSLECEAVEFRRQICELECEVHSLKE 876
            ||||    |:|.:| :|..:...:...|.:   :.|...:..|...:|.|.::.....|:..|||
Zfish   420 EDLL----SAKERECRELQESRRKESILVE---SWEDQARRAETTVIELRLELHNANSEILRLKE 477

  Fly   877 -------QLQLRQCALHDMEVQLTAARASVRCLERELENARDDIRVQKVDLEARKELCDKLDVER 934
                   :||....|......||:.....:..:|.:|..||.:....:.|||..:|||.|||..:
Zfish   478 RADSLENRLQQALSAERSCTSQLSQLNRKMIHMEEDLCQARAEHTQAQADLEKTRELCVKLDASK 542

  Fly   935 SKLNAELNDVNEIRKKLEKQ--CEKLRDELQQSLAINQVTNETTDLMLGRLHNDQQHQEDDDI-R 996
            ..:..||.......:.|:||  .|:|..:..:||.::     |.:..|.|....|:.|.:.:| :
Zfish   543 DAVQRELESCCSEIELLQKQLTSERLSVQTLESLLVS-----TREKELQRQLTSQERQTEIEILK 602

  Fly   997 SKHEM--------DRLQRQLQQTLDQLQEERVRCRHHEELAEKWEQQ--VRDLRR 1041
            .|..|        .|...||:....||:.:....:.|.. .|::|::  |::|||
Zfish   603 DKLSMADSKANSQSREMAQLKTRSCQLEADLEMTKRHLS-TERFERERAVQELRR 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	143/614 (23%)
Cep135	NP_001189108.1	DUF342	<302..421	CDD:302792	9/55 (16%)
tsga10	XP_005160173.1	COG4913	<16..308	CDD:227250	76/342 (22%)
		Smc	<174..521	CDD:224117	81/353 (23%)
		CALCOCO1	<421..>657	CDD:285171	63/249 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3312
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26335
orthoMCL	1	0.900	-	-		OOG6_104787
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.930