DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cep135 and Tsga10

DIOPT Version :9

Sequence 1:	NP_001189108.1	Gene:	Cep135 / 39647	FlyBaseID:	FBgn0036480	Length:	1065	Species:	Drosophila melanogaster
Sequence 2:	NP_001380638.1	Gene:	Tsga10 / 252923	RGDID:	621142	Length:	697	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	180/759 - (23%)
Similarity:	326/759 - (42%)	Gaps:	163/759 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 LNLLTRREEELQATNEKHKKKIQKMQAKILELQKELKDQNKHSNVTLDEEKIRLSSERDFFQKEY 434
            |....|..|||:...||:::.:.::|..:                     |: |:||||   |.:
  Rat    26 LKSTARDREELKCMLEKYERHLAEIQGNV---------------------KV-LTSERD---KTF 65

  Fly   435 LRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHGGKQQFSPQKSVQYETLPPPTASSITSTV 499
            |              |:.|.:   ||:..||.|:....|   ||:
  Rat    66 L--------------LYEQAQ---EEIARLRREMMKSCK---SPK-------------------- 90

  Fly   500 TSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHADELQALRLRNEELNDRL 564
                |....|.:.|||.|||.|.|:|.|:..|||:|||: |...|..|...:|      .|..|:
  Rat    91 ----STTAHAILRRVETERDVAFTDLRRMTTERDSLRER-LKIAQETAFNEKA------HLEQRI 144

  Fly   565 RQMERDNRELNSARLPTETNLVLLKEDLLQMRQRVASM-------QTEIDQLKTENDQITMLNDQ 622
            .::|.....|:..|:...:|:.|:||.:..:.:.:.|:       ::|:.:.|.||:.:.:|.:.
  Rat   145 EELECTVHNLDDERMEQMSNMTLMKETITTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYEN 209

  Fly   623 NERIIADYQSKLLVAERQRQSADVRASTLDSSRES-NRSEVTQLRMDLGALRQTYISLEHEKDTL 686
            .|:.::|.|..|...:.:.|....:...||...:: .|..:.| |.::..|..|...|..||:.|
  Rat   210 TEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ-REEISILGATLNDLAKEKECL 273

  Fly   687 LHQLDTKTERVYKLEYELKDCKEKRNALEQNVKDLEDQLRKLANRNRQRDSELTETSTESKTLRQ 751
            ...||.|:|.:..|...|. .|||      .:..:::.:.::...:||....|.....:...:|:
  Rat   274 QTCLDKKSENIASLGESLA-MKEK------TISGMKNIIAEMEQASRQSTEALIMCEQDISRMRR 331

  Fly   752 Q-------IVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSELQVANMKQQLHKYVQEV 809
            |       :..:...||....||..|.::.:..:.|.:.|.|||.|:..:::::||::.....||
  Rat   332 QLDETNDELGQIARERDILAHENDNLQEQFAKVKQENQALSKKLNDTHNELSDIKQKVQDTNLEV 396

  Fly   810 KKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQATLEGNNQSLECEAVEFRRQICELECEVHSL 874
            .|.:::|      |.:|.|...:::|.....:.....|...:.||.|....:.::...|.|.:.|
  Rat   397 NKLKNIL------KSEESENRQIMEQLRKANEDAENWENKARQLEAENNTLKLELITAEAEGNRL 455

  Fly   875 KEQLQLRQCALH-DMEVQLTAARA----------SVRCLERELENARDDIRVQKV----DLEARK 924
            ||::.    ||: ::|..|.|.|:          |:..:|.||:.    ::.:||    ||.:.:
  Rat   456 KEKVD----ALNREVEQHLNAERSYKSQIATLHKSLVKMEEELQK----VQFEKVSALADLSSTR 512

  Fly   925 ELCDKLDVERSKLNAELNDVNEIRKKLEKQCEKLRDELQQSLAINQVTNETTDLM----LGRLHN 985
            |||.|||..:..||.:|...::..:.:|.:.:..|.|::  |..:|:|||...:.    |...:.
  Rat   513 ELCIKLDSSKELLNRQLVAKDQEIEMMENELDSARSEIE--LLRSQMTNERISMQNLEALLVANR 575

  Fly   986 DQQHQEDDDIRSKH-EMDRLQRQL--------QQTLDQLQEERVRCRHHEEL--------AEKWE 1033
            |:::|....::.|. |:..|:..|        .|:.|..|...|..:...:|        .|::|
  Rat   576 DKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFE 640

  Fly  1034 QQ--VRDLRR-NLADDRYN----QARTREVSP-----RVPSKTL 1065
            ::  |::||| |.:.:.|:    :..|:..||     |.|.:.|
  Rat   641 RERAVQELRRQNYSSNAYHLGSMKPNTKCHSPERAHHRSPDRGL 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	149/622 (24%)
Cep135	NP_001189108.1	DUF342	<302..421	CDD:302792	8/50 (16%)
Tsga10	NP_001380638.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3120
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44837
orthoMCL	1	0.900	-	-		OOG6_104787
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970