DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep135 and Tsga10

DIOPT Version :9

Sequence 1:	NP_001189108.1	Gene:	Cep135 / 39647	FlyBaseID:	FBgn0036480	Length:	1065	Species:	Drosophila melanogaster
Sequence 2:	XP_011236763.1	Gene:	Tsga10 / 211484	MGIID:	2685063	Length:	903	Species:	Mus musculus

Alignment Length:	963	Identity:	221/963 - (22%)
Similarity:	408/963 - (42%)	Gaps:	202/963 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 NAGVFQ-KTTTTTKDGVTVTQTSGQEELDKMQNDLTAAGEQLEFFKRKVEARNREIRRLNDMLAG 246
            |...|| :....|:|....|.....|:|.:..:||.      |:.::.::::.....:::|
Mouse    44 NQNTFQLEQEVRTQDRFISTLKLQIEDLKQTNHDLE------EYVRKLLDSKEAVSTQVDD---- 98

  Fly   247 GRPLAALAKDCCYKDVGALSQDIDLLQREKSDLMMQVREFQDK-MHDAMQRALSSEEDKIKLQTQ 310
               ||...:..| |::..|.|..:.||:||:.::    :..|| :.:|....:..:.:...|:..
Mouse    99 ---LANHNEHLC-KELIKLDQLAEKLQKEKNFVV----DTADKELEEAKIELICQQNNITVLEDT 155

  Fly   311 LEELKEAALQVEQQAN--------------AEIDAKESELRQLQLELKKKGKDHRLTGGFASNQS 361
            ::.||...|:.|:..|              |:.|..::|.:.|:..::.:.|..|.    .|..|
Mouse   156 IQRLKSIILETEKAQNTSPSRLDSFVKTLEADRDYYKTEAQNLRKMMRNRSKSPRR----PSPTS 216

  Fly   362 DKHNLN-ERLNLLTRREEELQATNEKHKKKIQKMQAKILELQKELKDQNKHSNVTLDEEKIRLSS 425
            ...|.: |.|....|..|||:...||:::.:.::|..:                     |: |:|
Mouse   217 RAANCDVELLKSTARDREELKCMLEKYERHLAEIQGNV---------------------KV-LTS 259

  Fly   426 ERDFFQKEYLRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHGGKQQFSPQKSVQYETLPPP 490
            |||   |.:|              |:.|.:   ||:..||.|:....|   ||:
Mouse   260 ERD---KTFL--------------LYEQAQ---EEIARLRREMMKSCK---SPK----------- 290

  Fly   491 TASSITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHADELQALRL 555
                         |....|.:.|||.|||.|.|:|.|:..|||:|||: |...|..|...:|
Mouse   291 -------------STTAHAILRRVETERDVAFTDLRRMTTERDSLRER-LKIAQETAFNEKA--- 338

  Fly   556 RNEELNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMRQRVASM-------QTEIDQLKTEN 613
               .|..|:.::|.....|:..|:....|:.|:||.:..:.:.:.|:       ::|:.:.|.||
Mouse   339 ---HLEQRIEELECTVHNLDDERMEQMANMTLMKETITTVEKEMKSLARKAMDTESELGRQKAEN 400

  Fly   614 DQITMLNDQNERIIADYQSKLLVAERQRQSADVRASTLDSSRES-NRSEVTQLRMDLGALRQTYI 677
            :.:.:|.:..|:.::|.|..|...:.:.|....:...||...:: .|..:.| |.::..|..|..
Mouse   401 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ-REEISILGATLN 464

  Fly   678 SLEHEKDTLLHQLDTKTERVYKLEYELKDCKEKRNALEQNVKDLEDQLRKLANRNRQRDSELTET 742
            .|..||:.|...||.|:|.:..|...|. .|||      .:..:::.:.::...:||....|...
Mouse   465 DLAKEKECLQACLDKKSENIASLGESLA-MKEK------TISGMKNIIAEMEQASRQSTEALIMC 522

  Fly   743 STESKTLRQQ-------IVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSELQVANMKQ 800
            ..:...:|:|       :..:...||....||..|.::.:..:.|.:.|.|||.|:..:::::||
Mouse   523 EQDISRMRRQLDETNDELGQIARERDILAHENDNLQEQFAKVKQENQALSKKLNDTHNELSDIKQ 587

  Fly   801 QLHKYVQEVKKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQATLEGNNQSLECEAVEFRRQIC 865
            ::.....||.|.:::|      |.:|.|...:::|.....:.....|...:..|.|....:.::.
Mouse   588 KVQDTNLEVNKLKNIL------KSEESENRQIMEQLRKANEDAENWENKARQTEAENNTLKLELI 646

  Fly   866 ELECEVHSLKEQLQLRQCALH-DMEVQLTAARA----------SVRCLERELENARDDIRVQKV- 918
            ..|.|.:.|||::.    ||: ::|..|.|.|:          |:..:|.||:.    ::.:||
Mouse   647 TAEAEGNRLKEKVD----ALNREVEQHLNAERSYKSQIATLHKSLVKMEEELQK----VQFEKVS 703

  Fly   919 ---DLEARKELCDKLDVERSKLNAELNDVNEIRKKLEKQCEKLRDELQQSLAINQVTNETTDLM- 979
               ||.:.:|||.|||..:..||.:|...::..:.:|.:.:..|.|::  |..:|:|||...:.
Mouse   704 ALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMMENELDSARSEIE--LLRSQMTNERISMQN 766

  Fly   980 ---LGRLHNDQQHQEDDDIRSKH-EMDRLQRQL--------QQTLDQLQEERVRCRHHEEL---- 1028
               |...:.|:::|....::.|. |:..|:..|        .|:.|..|...|..:...:|
Mouse   767 LEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITK 831

  Fly  1029 ----AEKWEQQ--VRDLRR-NLADDRYN----QARTREVSP-----RVPSKTL 1065
                .|::|::  |::||| |.:.:.||    :..|:..||     |.|.:.|
Mouse   832 RQLGTERFERERAVQELRRQNYSSNAYNLGPMKPNTKCHSPERAHHRSPDRGL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	183/805 (23%)
Cep135	NP_001189108.1	DUF342	<302..421	CDD:302792	24/133 (18%)
Tsga10	XP_011236763.1	Smc	<224..>834	CDD:224117	166/709 (23%)
Tsga10	XP_011236763.1	SMC_prok_A	423..>698	CDD:274009	65/296 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3249
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42777
orthoMCL	1	0.900	-	-		OOG6_104787
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.920