Protein Alignment Cep135 and Cep135

DIOPT Version :10

• Sequence 1: NP_001189108.1
• Gene: Cep135 / 39647
• FlyBaseID: FBgn0036480
• Length: 1065
• Species: Drosophila melanogaster
• Sequence 2: XP_309709.5
• Gene: Cep135 / 1270971
• VectorBaseID: AGAMI1_004773
• Length: 1442
• Species: Anopheles gambiae
• Alignment Length: 1131
• Identity: 367/1131 - (32%)
• Similarity: 589/1131 - (52%)
• Gaps: 149/1131 - (13%)

  Fly    10 DLRCKLDIMGFTQTLPVLAIPLVQAVFGDLIKTTECLRDTKKKVAELLEEKTCWELGVEPYKCDN 74
            :||.:||::||...||:.||.:|.|:..|||:|:|.|:...:::.:|.:||:.||||||||||||
Mosquito     9 ELRTRLDVLGFGHPLPLSAIGIVSAILDDLIQTSEKLKCANQRIEQLHQEKSAWELGVEPYKCDN 73

  Fly    75 SRLLAECNELHLQFLRDREDYELRLCESERKIRNLELDKQHLQSHNDGLQRQLDALLTKQMVSSV 139
            ||||||||.|||:.::.::.:.|...|...::|:|:.||:.|:......:.::..|.|... .||
Mosquito    74 SRLLAECNALHLELIKQQDKHILANTELRSRVRSLQADKKQLEEKCLAAECKIRELQTGSS-ESV 137

  Fly   140 TNKKATAGIGRQTKKPFITTVRSGIAMPTTLGTSSSALKCTKCNAGVFQKTTTTTKDGVTVT--- 201
            .::|.||   .:.:||||:|||:        ||.....||  |..|..|:     ..|:..|
Mosquito   138 KSRKDTA---NKQRKPFISTVRA--------GTFYQPPKC--CEQGGMQQ-----PGGMPPTCRC 184

  Fly   202 ------QTSGQEELDKMQNDLTAAGEQLEFFKRKVEARNREIRRLNDMLAGGRPLAALAKDCCYK 260
                  |.....|:::::.:.......::..|.:|.:|:|||:||..:.|||||.|||||||||:
Mosquito   185 PCNQMKQVDVLHEVERLRVETQNQQGVIDALKNQVNSRDREIQRLGALFAGGRPAAALAKDCCYR 249

  Fly   261 DVGALSQDIDLLQREKSDLMMQVREFQDKMHDAMQRALSSEEDKIKLQTQLEELKEAALQVEQQA 325
            ||..|..|:..||:||..|...:.|.|.......::.....|...:|:.:|.|.:.||:::|.:|
Mosquito   250 DVNELGHDVATLQQEKLSLQQTLTEAQQTQERTARKLSRLSEKNQQLEKELREFESAAIKLESEA 314

  Fly   326 N---AEIDAKESEL-----------RQLQ--LELKKKG------------------KDHRLTGGF 356
            |   .|.|.|.|:|           |:|:  |||...|                  .|..|....
Mosquito   315 NRKMLEHDRKNSDLQVKLQQSQVRVRELESLLELCGPGAGKVRPPPDSSISSSTCPSDAMLQTAL 379

  Fly   357 ASNQSDKHNLNERLNLLTRREEELQATNEKHKKKIQKMQAKILELQKELKDQ-----NKHSNVTL 416
            .....:|..|.::||.|..||:.|.|..||.|.|..:::.|...|::....|     :..|.|.|
Mosquito   380 QQATDEKRLLYKQLNELKDREQSLLADFEKVKTKYTRLKQKHAALEQTQHHQLVGSVSAESQVEL 444

  Fly   417 D---------EEKIR-LSSERDFFQKEYLRLMSKTGSESEIAFLHAQIKSKDEELKALRSELFHG 471
            .         |||:| ...|||.:..:..|      ..:.::.|..:...||.||..|::||
Mosquito   445 QSLQYRCSELEEKLRHTKQERDRYSSDAER------QRTVVSQLKRESVEKDHELAELKNEL--- 500

  Fly   472 GKQQFSPQKSVQYETLPPPTAS--------SITSTVTSNTSDCVQAAIARVERERDCARTELERV 528
                     ..|.::..|.|||        :..|..:..:|..|||||.|:|||||.|::|:.::
Mosquito   501 ---------HAQRKSNRPSTASQGGGGRLRTADSHGSGQSSLSVQAAIHRIERERDAAKSEVRQL 556

  Fly   529 RCERDTLREK-QLST------VQLHADELQALRLRNEELNDRLRQMERDNRELNSARLPTETNLV 586
            ..|||.|||| :|||      |..|.:.:       .|.:.|:..:|.:.|:|...:...:..:.
Mosquito   557 EQERDALREKLKLSTRSQQDAVAKHENAI-------AEYSSRVATLEAEKRDLQGGQAAAQMKVK 614

  Fly   587 LLKEDLLQMRQRVASMQTEIDQLKTENDQITMLNDQNERIIADYQSKLLVAERQRQSADVRASTL 651
            ||||:..:::.||..::....:||....|:.:|::|.||.:|.:|.:||..:.|..:|:.:...:
Mosquito   615 LLKEESRELQARVKELEESYSKLKLSYSQMKILHEQTERALAQHQQRLLSTQTQLGTAESKLQRV 679

  Fly   652 DSSRESNRSEVTQLRMDLGALRQTYISLEHEKDTLLHQLDTKTERVYKLEYELKDCKEKRNALEQ 716
            ||:.|..::||.:|:.::..||.:..||..|||.||..||.|||.:|..|.|:.:.|.||..|:.
Mosquito   680 DSTVEDAQNEVGRLKGEISLLRASNASLVREKDKLLMDLDKKTENLYAAEAEIAELKAKRKELKS 744

  Fly   717 NVKDLEDQLRKLANRNRQRDSELTETSTESKTLRQQIVALKASRDEAIAENRRLMDKLSDAQVEA 781
            .:..::.:|..::..|..::|.|...|||:.||:||:..||...|.|..||.||.::|:||..|.
Mosquito   745 TIDRMQQKLDNVSTDNIHKESTLRSVSTETDTLKQQMATLKRKNDNASTENGRLSNELTDALAEL 809

  Fly   782 RTLQKKLTDSELQVANMKQQLHKYVQEVKKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQATL 846
            ...:::|.||:.:|..||.||.:||||:::||:||::      ||:||:.||:::..|::|...|
Mosquito   810 TLTKRQLKDSQQEVERMKTQLREYVQEMQRAEELLLE------KERERESMLERFKSLSEGVNVL 868

  Fly   847 EGNNQSLECEAVEFRRQICELECEVHSLKEQLQLRQCALHDMEVQLTAARASVRCLERELENARD 911
            |.:|.:||.|..|.|:.:.|.|..:.:|:|....|:..:.:.|.|:....||:...|.|||..|:
Mosquito   869 ETSNHTLEAETSEARKLLQEAEERIATLEELTNEREQNIRECEHQINELSASLAAAESELEALRE 933

  Fly   912 DIRVQKVDLEARKELCDKLDVERSKLNAELNDVNEIRKKLEKQCEKLRDELQQSLAINQ------ 970
            :.:...:||||.||||.|||:::.||.|||.:.:.||::|.::    :..||:.|.:.:
Mosquito   934 ENKALALDLEATKELCGKLDLQKDKLQAELEEHSNIREQLARE----KGTLQRELTLTRTGDRAA 994

  Fly   971 -------VTNETTDLMLGRLHNDQQHQEDDDIRSKHEMDRLQRQLQQTLDQLQEERVRCRHHEEL 1028
                   :|....||...||...||.||.:.:|:  |:|.|:       .::.:|:.:.|..|.|
Mosquito   995 VDGLQELLTASRADLEQHRLALAQQQQETEKLRT--EVDALR-------SRMADEQDKARRSEAL 1050

  Fly  1029 AEKWEQQVRDLRRNLADDRYNQARTR 1054
            |.::..|:::|||.|.|:|:...|:|
Mosquito  1051 ASEYGVQLQELRRQLTDERFALMRSR 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	DR0291	206..>346	CDD:441187	53/155 (34%)
		SMC_prok_B	286..1044	CDD:274008	254/834 (30%)
Cep135	XP_309709.5	None