DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and URA8

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_012637.4	Gene:	URA8 / 853567	SGDID:	S000003864	Length:	578	Species:	Saccharomyces cerevisiae

Alignment Length:	586	Identity:	317/586 - (54%)
Similarity:	413/586 - (70%)	Gaps:	21/586 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||::|:||||||:||||:|||.|.|||:.||.|||||||||:||||||.||.||||.:|||||.
Yeast     1 MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGG 65

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            |.|||||||||:|.:||.||:||||||||..||.:||.|:|||||||:|||:|:|||:|::||::
Yeast    66 ETDLDLGNYERYLGITLSRDHNITTGKIYSHVISRERRGDYLGKTVQIVPHLTNAIQDWIQRVSK 130

  Fly   131 TPVQGSS-KPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            .||..:. :|.|||:|||||:||||..|||||.|||||.|.||||.|.||||||:  ..||.|||
Yeast   131 IPVDDTGLEPDVCIIELGGTVGDIESAPFVEALRQFQFEVGRENFALIHVSLVPV--IHGEQKTK 193

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||:::::||..||.||:|.||..:.:.....:||:.||||||:||:.:||:||.||||||:.:.
Yeast   194 PTQAAIKDLRSLGLIPDMIACRCSEELNRSTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLKQ 258

  Fly   260 GVIEYLNERLQLN------IDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVV 318
            .:|:||:.||:|.      .|..:.::.|..|.::.:..:.....|.||:|||||...|||.||.
Yeast   259 HMIDYLHSRLKLGEVPLTLEDKERGSQLLTNWENMTKNLDDSDDVVKIALVGKYTNLKDSYLSVT 323

  Fly   319 KALQHAALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIR 383
            |:|:||::...|:||::::|:..||.||...:.:|:|..|.||..:.|||||||||:||:||.|.
Yeast   324 KSLEHASMKCRRQLEILWVEASNLEPETQEVDKNKFHDSWNKLSSADGILVPGGFGTRGIEGMIL 388

  Fly   384 ACQWARENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANA----LVIDMPEHHTGQL 444
            |.:||||:..|.||:|||||.|.||||||.:|..::::||....|..|    :||.|||.....:
Yeast   389 AAKWARESGVPFLGVCLGLQVAAIEFARNVIGRPNSSSTEFLDETLLAPEDQVVIYMPEIDKEHM 453

  Fly   445 GGTMRLGKRITVFSDGP--SVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKT 507
            |||||||.|.|:|....  |.||:|||....|.||||||||:|||.|:.:|.:|..|||.|....
Yeast   454 GGTMRLGLRPTIFQPNSEWSNIRKLYGEVNEVHERHRHRYEINPKIVNDMESRGFIFVGKDETGQ 518

  Fly   508 RMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQLSDASSD 572
            |.||.||.||||:|.|||||||.|:.|:||.||.||:.|:...|.:.|:      ...||:.:.:
Yeast   519 RCEIFELKGHPYYVGTQYHPEYTSKVLEPSRPFWGLVAAASGTLGEVIK------DINLSEGNEN 577

  Fly   573 E 573
            |
Yeast   578 E 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	313/567 (55%)
		CTP_synth_N	2..271	CDD:283956	172/269 (64%)
		GATase1_CTP_Synthase	299..544	CDD:153217	133/250 (53%)
URA8	NP_012637.4	PyrG	1..557	CDD:273021	311/557 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344375
Domainoid	1	1.000	362	1.000	Domainoid score	I127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20446
Inparanoid	1	1.050	618	1.000	Inparanoid score	I122
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60688
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm46785
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	O	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
TreeFam	0	0.000	Not matched by this tool.
	13	12.930