DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and URA7

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_009514.1	Gene:	URA7 / 852241	SGDID:	S000000135	Length:	579	Species:	Saccharomyces cerevisiae

Alignment Length:	567	Identity:	312/567 - (55%)
Similarity:	405/567 - (71%)	Gaps:	13/567 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||::|:||||||:||||:|||.|.|:|:.||.|||||||||:||||||.||.||||.:|||||.
Yeast     1 MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGG 65

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            |.|||||||||:|.|||.:|:||||||||..||.|||.|:|||||||:|||:|:|||:|:||||:
Yeast    66 ETDLDLGNYERYLGVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQDWIERVAK 130

  Fly   131 TPVQGSS-KPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            .||..:. :|.|||:|||||:||||..|||||.|||||:|.:|||.|.||||||:  ..||.|||
Yeast   131 IPVDDTGMEPDVCIIELGGTVGDIESAPFVEALRQFQFKVGKENFALIHVSLVPV--IHGEQKTK 193

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||::::.||..||.||:|.||..:.:.....:||:.||||||:||:.:||:||.||||||:.:.
Yeast   194 PTQAAIKGLRSLGLVPDMIACRCSETLDKPTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLEQ 258

  Fly   260 GVIEYLNERLQLN-IDMSKRTK-----CLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVV 318
            .:|:||:.||:|: |.:::..|     .|.:|:......:.....|.||:|||||...|||.||:
Yeast   259 KMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDESMETVKIALVGKYTNLKDSYLSVI 323

  Fly   319 KALQHAALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIR 383
            |||:|:::...|||::.::|:..||.|...|..:|:|:.|..:..:.|||:|||||.||.||.:.
Yeast   324 KALEHSSMKCRRKLDIKWVEATDLEPEAQESNKTKFHEAWNMVSTADGILIPGGFGVRGTEGMVL 388

  Fly   384 ACQWARENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDP--NTANALVIDMPEHHTGQLGG 446
            |.:|||||..|.||:|||||.|.|||.|:.||.||:::.|..|  :..|.:|:.|||.....:||
Yeast   389 AARWARENHIPFLGVCLGLQIATIEFTRSVLGRKDSHSAEFYPDIDEKNHVVVFMPEIDKETMGG 453

  Fly   447 TMRLGKRITVFSDGP--SVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRM 509
            :||||.|.|.|.:..  |.|::|||:...|.||||||||:|||.|..||..|:.|||.|....|.
Yeast   454 SMRLGLRPTFFQNETEWSQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGKDDTGKRC 518

  Fly   510 EIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQ 556
            ||:||..|||::||||||||.|:.|.||.|||||:.||...|...|:
Yeast   519 EILELKNHPYYIATQYHPEYTSKVLDPSKPFLGLVAASAGILQDVIE 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	311/565 (55%)
		CTP_synth_N	2..271	CDD:283956	173/269 (64%)
		GATase1_CTP_Synthase	299..544	CDD:153217	128/248 (52%)
URA7	NP_009514.1	PyrG	1..555	CDD:273021	308/555 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344376
Domainoid	1	1.000	362	1.000	Domainoid score	I127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I122
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60688
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm46785
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	LDO	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
TreeFam	0	0.000	Not matched by this tool.
	12	11.930