DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and Ctps2

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001030170.1	Gene:	Ctps2 / 619580	RGDID:	1563369	Length:	586	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	380/575 - (66%)
Similarity:	456/575 - (79%)	Gaps:	5/575 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||||||||||||:|||:||||.||:||||||.||:||||||||||||||||||||||:||:||.
  Rat     1 MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGG 65

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            ||||||||||||||:.|::||||||||||:.||.|||.|:|||||||||||||||||:||...|:
  Rat    66 EVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQDWVMNQAK 130

  Fly   131 TPVQGSSK-PQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            ..|.|:.: ||:|::||||||||||||.||||||||||:.|||||...||||||.|.||||.|||
  Rat   131 VSVDGNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKRENFYNIHVSLVPQPSATGEQKTK 195

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||:|||.|||.|||||||||||..||.:.||||||.||||.|:|||||||::|||.||||:|:.
  Rat   196 PTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQ 260

  Fly   260 GVIEYLNERLQLNI-DMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQH 323
            ||::|..|||.|.| |.|  ...|.:|:.:|.|.|.:::...||:||||||..|.||||.|||:|
  Rat   261 GVVKYFQERLDLPINDCS--NNLLFKWKTMADRYERLQKICSIALVGKYTKLRDCYASVFKALEH 323

  Fly   324 AALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWA 388
            :|||:|.||.|::|:|..||..|...:|.|:|:.|||||.:.|||||||||.||..||::|..||
  Rat   324 SALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWA 388

  Fly   389 RENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKR 453
            |..:.|.||||||:|.||||||||.|.|||||:||.||||...||||||||:.|.||||||||.|
  Rat   389 RTKKIPFLGICLGMQLAVIEFARNCLNLKDANSTEFDPNTPVPLVIDMPEHNPGDLGGTMRLGLR 453

  Fly   454 ITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHP 518
            .|||:...|::::|||:...::|||||||||||..::..|.:.:.|||.|||..|||||||:|||
  Rat   454 RTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIIELTGHP 518

  Fly   519 YFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQL-SDASSD 572
            ||:..|:|||:.|||:|||||:|||:||:...||.::|:..:||...: ||||.|
  Rat   519 YFIGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNTHLQQMSKLSYSDIYSDASDD 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	372/556 (67%)
		CTP_synth_N	2..271	CDD:283956	206/269 (77%)
		GATase1_CTP_Synthase	299..544	CDD:153217	151/244 (62%)
Ctps2	NP_001030170.1	PLN02327	1..557	CDD:215186	372/557 (67%)
		CTP_synth_N	2..272	CDD:283956	206/269 (77%)
		GATase1_CTP_Synthase	299..544	CDD:153217	151/244 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343355
Domainoid	1	1.000	430	1.000	Domainoid score	I573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	810	1.000	Inparanoid score	I457
OMA	1	1.010	-	-		QHG60688
OrthoDB	1	1.010	-	-		D161130at33208
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm45397
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	O	PTHR11550
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X676
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910