DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and Ctps2

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001345327.1	Gene:	Ctps2 / 55936	MGIID:	1933185	Length:	635	Species:	Mus musculus

Alignment Length:	577	Identity:	375/577 - (64%)
Similarity:	454/577 - (78%)	Gaps:	7/577 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||||||||||||:|||:||||.||:||||||.||:||||||||||||||||||||||:||:||.
Mouse    50 MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGG 114

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            ||||||||||||||:.|::||||||||||:.||.|||.|:||||||||||||||||||||...|:
Mouse   115 EVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAK 179

  Fly   131 TPVQGSSK-PQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            ..|.|:.: ||:|::||||||||||||.||||||||||:.|:|||...||||||.|.||||.|||
Mouse   180 VSVDGNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKTK 244

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||:|||.|||.|||||||||||..||.:.||||||.||||.|:|||||||::|||.||||:|:.
Mouse   245 PTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQ 309

  Fly   260 GVIEYLNERLQLNI-DMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQH 323
            ||::|..|||.|.| |.|  :..|.:|:.:|.|.|.:::...||:||||||..|.||||.|||:|
Mouse   310 GVVKYFQERLGLPINDCS--SNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCYASVFKALEH 372

  Fly   324 AALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWA 388
            :|||:|.||.|::|:|..||..|...:|.|:|:.|||||.:.|||||||||.||..||::|..||
Mouse   373 SALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWA 437

  Fly   389 RENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKR 453
            |..:.|.||||||:|.||||||||.|.|||||:||.:|||...||||||||:.|.||||||||.|
Mouse   438 RTKKIPFLGICLGMQLAVIEFARNCLNLKDANSTEFEPNTPVPLVIDMPEHNPGDLGGTMRLGLR 502

  Fly   454 ITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHP 518
            .|||:...|::::|||:...::|||||||||||..::..|.:.:.|||.|||..||||:||:.||
Mouse   503 RTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIVELTSHP 567

  Fly   519 YFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQLSDASSDEED 575
            ||:..|:|||:.|||:|||||:|||:||:...||.::|   :::....||..||..|
Mouse   568 YFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQ---QMNKLPYSDGYSDASD 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	369/556 (66%)
		CTP_synth_N	2..271	CDD:283956	206/269 (77%)
		GATase1_CTP_Synthase	299..544	CDD:153217	148/244 (61%)
Ctps2	NP_001345327.1	PLN02327	50..606	CDD:215186	370/560 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839536
Domainoid	1	1.000	431	1.000	Domainoid score	I582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	812	1.000	Inparanoid score	I479
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60688
OrthoDB	1	1.010	-	-		D161130at33208
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm43326
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	O	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940