DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and Ctps1

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001128345.1	Gene:	Ctps1 / 313560	RGDID:	1311060	Length:	591	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	391/594 - (65%)
Similarity:	475/594 - (79%)	Gaps:	9/594 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||||||||||||:||||||||.||:||||||.|||||||||||||||||||||||||:|||||.
  Rat     1 MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGG 65

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            ||||||||||||||:.|.:|||:||||||:.||.|||.|:||||||||||||||||||||.|.|.
  Rat    66 EVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQAL 130

  Fly   131 TPV-QGSSKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            .|| :...:||||::|||||:||||.|||:||||||||:||:||||..||||||.|.:|||.|||
  Rat   131 IPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKKENFCNIHVSLVPQPSSTGEQKTK 195

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||:|||||||.||||||:|||...|:...||||||.||||.|:||||:||::|||.||||:|:.
  Rat   196 PTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQ 260

  Fly   260 GVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQHA 324
            ||::|...||.|.::...| |.|.:|:::|.|.:.:.....||:|||||||:||||||:|||:|:
  Rat   261 GVVDYFLRRLDLPVERQSR-KMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHS 324

  Fly   325 ALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWAR 389
            |||:|.|||:.:|:|..||..||..||.:||:.|||||.:||:|||||||.||.||||:|..|||
  Rat   325 ALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWAR 389

  Fly   390 ENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKRI 454
            :.:||.||:|||:|.||:||:||.||.:|||:||.||.|::.:|||||||:.||:|||||||||.
  Rat   390 KQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPKTSHPVVIDMPEHNPGQMGGTMRLGKRR 454

  Fly   455 TVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHPY 519
            |:|....||:|:|||:...::||||||:||||.....|||||::|||.||:..||||:||..||:
  Rat   455 TLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPF 519

  Fly   520 FVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQLSDASSDEEDSVVGLAGAT 584
            ||..|||||:||||:|||||:.||:||||.||..|:|:|||||||   |..||..    |.:...
  Rat   520 FVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPR---DTYSDRS----GSSSPD 577

  Fly   585 KSLSSLKIP 593
            ..::.||.|
  Rat   578 SEITELKFP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	376/555 (68%)
		CTP_synth_N	2..271	CDD:283956	205/269 (76%)
		GATase1_CTP_Synthase	299..544	CDD:153217	155/244 (64%)
Ctps1	NP_001128345.1	PLN02327	1..556	CDD:215186	376/555 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343354
Domainoid	1	1.000	430	1.000	Domainoid score	I573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20446
Inparanoid	1	1.050	810	1.000	Inparanoid score	I457
OMA	1	1.010	-	-		QHG60688
OrthoDB	1	1.010	-	-		D161130at33208
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm45397
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	LDO	PTHR11550
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910