DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTPsyn and cts1

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_593254.1	Gene:	cts1 / 2542937	PomBaseID:	SPAC10F6.03c	Length:	600	Species:	Schizosaccharomyces pombe

Alignment Length:	591	Identity:	335/591 - (56%)
Similarity:	418/591 - (70%)	Gaps:	17/591 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||:||:||||||:||||||||.|.|||:.||.|||||||||:||||||.||.|||||:||:||.
pombe     1 MKYVLVSGGVISGIGKGVIASSTGLLLKTLGLKVTSIKIDPYMNIDAGTMSPLEHGEVFVLNDGG 65

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            |||||||||||:|:|||..||||||||:|..||:|||.|:|||||||:|||:|:.||:||||||:
pombe    66 EVDLDLGNYERYLNVTLTHDNNITTGKVYSNVIQKERRGDYLGKTVQIVPHVTNEIQDWVERVAR 130

  Fly   131 TPV-QGSSKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            .|| |...:|.|||||||||:||||...||||.|||||||..|||...||||||:  ..||.|||
pombe   131 IPVDQSGEEPDVCIVELGGTVGDIESAAFVEAMRQFQFRVGHENFVSIHVSLVPV--INGEQKTK 193

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||.::|:||..|::||||.||.::|:...|.:|||.||||||:||:.:||::|.||||.|:|..
pombe   194 PTQQAIRDLRSLGITPDLIACRCKQPLEKSVIDKISLFCHVGPEQVLAVHDVSSTYHVPQLLEDK 258

  Fly   260 GVIEYLNERLQLN-IDMSKR-----TKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVV 318
             ::|||..|..|: |.:|:.     ......|:.|.:..:.:.::|.|.:|||||...|||.||:
pombe   259 -LLEYLKIRFALDKISVSRELALAGENMWSSWKHLTQGYDHLFKKVTIVLVGKYTHLQDSYISVI 322

  Fly   319 KALQHAALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIR 383
            |||:|:|:...|||:|.::|:..||..|..|:|..|||.|..:|.::||||||||||||:||.|.
pombe   323 KALEHSAMRCGRKLDLQWVEASHLEASTNTSDPLSYHKAWHLVCSANGILVPGGFGSRGVEGMIA 387

  Fly   384 ACQWARENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTM 448
            |.:|||||..|.||||||:|.|||||||:..|::.|.:.|.|....|.:|:.|||....:|||||
pombe   388 AAKWARENNTPYLGICLGMQVAVIEFARSVCGIEGAFSEEFDKECENNVVVYMPEIDKDKLGGTM 452

  Fly   449 RLGKRITVFSDGP--SVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEI 511
            |||.|.|.|....  |.:|:|:.....|.||||||||:||.:|..||:.|:.|:|.|....||||
pombe   453 RLGLRPTFFQPNSEWSKLRKLHKMVDEVLERHRHRYEINPAFVSRLEQGGISFIGKDERGERMEI 517

  Fly   512 IELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRG-----CRLSPRQLSDASS 571
            ||...|||||..||||||||:|||||||..||:.||...|:::||.|     ...|......|.:
pombe   518 IEKRDHPYFVGVQYHPEYLSKPLKPSPPIFGLVAASAGLLDEFIQSGEEVEWSNFSHFNAESALA 582

  Fly   572 DEEDSV 577
            |..|||
pombe   583 DMNDSV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	326/563 (58%)
		CTP_synth_N	2..271	CDD:283956	180/269 (67%)
		GATase1_CTP_Synthase	299..544	CDD:153217	136/246 (55%)
cts1	NP_593254.1	PLN02327	1..563	CDD:215186	327/564 (58%)
		CTP_synth_N	2..269	CDD:283956	180/269 (67%)
		GATase1_CTP_Synthase	303..550	CDD:153217	136/246 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	361	1.000	Domainoid score	I152
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I130
OMA	1	1.010	-	-		QHG60688
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		oto101195
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	LDO	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
TreeFam	0	0.000	Not matched by this tool.
	11	11.000