DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTPsyn and CTPS1

DIOPT Version :9

Sequence 1:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_024309320.1	Gene:	CTPS1 / 1503	HGNCID:	2519	Length:	598	Species:	Homo sapiens

Alignment Length:	594	Identity:	390/594 - (65%)
Similarity:	475/594 - (79%)	Gaps:	9/594 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65
            |||||||||||||:|||:||||.||:||||||.|||||||||||||||||||||||||:|||||.
Human     8 MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGG 72

  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130
            ||||||||||||||:.|.:|||:||||||:.||.|||.|:||||||||||||||||||||.|.|.
Human    73 EVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQAL 137

  Fly   131 TPV-QGSSKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194
            .|| :...:||||::|||||:||||.|||:||||||||:|||||||..||||||.|.:|||.|||
Human   138 IPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTK 202

  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259
            |||:|||||||.||||||:|||...|:...||||||.||||.|:||||:||::|||.||||:|:.
Human   203 PTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQ 267

  Fly   260 GVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQHA 324
            ||::|...||.|.|:...| |.|.:|:::|.|.:.:.....||:|||||||:||||||:|||:|:
Human   268 GVVDYFLRRLDLPIERQPR-KMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHS 331

  Fly   325 ALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWAR 389
            |||:|.|||:.:|:|..||..|...||.:||:.|||||.:||:|||||||.||.||||:|..|||
Human   332 ALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWAR 396

  Fly   390 ENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKRI 454
            ..:||.||:|||:|.||:||:||.||.:|||:||.||.|::.:|:|||||:.||:|||||||||.
Human   397 NQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRR 461

  Fly   455 TVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHPY 519
            |:|....||:|:|||:...::||||||:||||.:...|||||::|||.||:..||||:||..||:
Human   462 TLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPF 526

  Fly   520 FVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPRQLSDASSDEEDSVVGLAGAT 584
            ||..|||||:||||:|||||:.||:||||.||:.|:|:|||||||   |..||..    |.:...
Human   527 FVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPR---DTYSDRS----GSSSPD 584

  Fly   585 KSLSSLKIP 593
            ..::.||.|
Human   585 SEITELKFP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	375/555 (68%)
		CTP_synth_N	2..271	CDD:283956	205/269 (76%)
		GATase1_CTP_Synthase	299..544	CDD:153217	153/244 (63%)
CTPS1	XP_024309320.1	PLN02327	8..563	CDD:215186	375/555 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149478
Domainoid	1	1.000	429	1.000	Domainoid score	I597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20446
Inparanoid	1	1.050	809	1.000	Inparanoid score	I490
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60688
OrthoDB	1	1.010	-	-		D161130at33208
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm41268
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	LDO	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940