Protein Alignment GlyRS and GRS1

DIOPT Version :10

• Sequence 1: NP_730022.1
• Gene: GlyRS / 39644
• FlyBaseID: FBgn0027088
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_009679.2
• Gene: GRS1 / 852418
• SGDID: S000000325
• Length: 667
• Species: Saccharomyces cerevisiae
• Alignment Length: 679
• Identity: 319/679 - (46%)
• Similarity: 434/679 - (63%)
• Gaps: 58/679 - (8%)

  Fly   122 DVKKAVAELKARKKLLEDKELALTPSVVSFDRAKMEDLLKRRFFYDQSFAIYGGITGQYDFGPMG 186
            |:|||.|                   .|.|:|.::|.:|:.||||..:|.:|||::|.||:||.|
Yeast     5 DIKKARA-------------------AVPFNREQLESVLRGRFFYAPAFDLYGGVSGLYDYGPPG 50

  Fly   187 CALKSNILALWRQYFALEEQMLEVDCSILTPEPVLKASGHVERFADLMVKDVKTGECFRLDHLIK 251
            ||.::||:..||::|.|||.||||||::|||..|||.||||::|:|.|.:|:||||.||.|||::
Yeast    51 CAFQNNIIDAWRKHFILEEDMLEVDCTMLTPYEVLKTSGHVDKFSDWMCRDLKTGEIFRADHLVE 115

  Fly   252 QALEKLSK--------AKDATPALQ-------------------------AECEDIIIKLDGLNK 283
            :.||...|        .:||..|.:                         .|.|:|:.|:||.:.
Yeast   116 EVLEARLKGDQEARGLVEDANAAAKDDAEKKKRKKKVKQIKAVKLDDDVVKEYEEILAKIDGYSG 180

  Fly   284 QELAGVLAKYNIKSPLTGNDLTEPIEFNLMFATQIGPTGLVKGFLRPETAQGIFVNFKRLLEFNQ 348
            .||..::.||:|.:|:||..|..|..|||||.|.|||:|.:||:||||||||.|:||.:|||||.
Yeast   181 PELGELMEKYDIGNPVTGETLESPRAFNLMFETAIGPSGQLKGYLRPETAQGQFLNFNKLLEFNN 245

  Fly   349 GKLPFAVAQIGNSFRNEISPRSGLIRVREFTMAEIEHFCDPVLKDHPKFGNIKSEKLTLYSACNQ 413
            .|.|||.|.||.|||||||||:||:|||||.|||||||.||:.|.||||..||..||:......|
Yeast   246 SKTPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPLDKSHPKFNEIKDIKLSFLPRDVQ 310

  Fly   414 MDGKSAAQVQ-IGEAVASKLVANETLGYYMARIQQFLLAIGIKPECLRFRQHMSNEMAHYACDCW 477
            ..|.:...|: :||||||::|.||||||::|||.|||:.||:....|||||||:|||||||.|||
Yeast   311 EAGSTEPIVKTVGEAVASRMVDNETLGYFIARIYQFLMKIGVDESKLRFRQHMANEMAHYAADCW 375

  Fly   478 DAEILTSYGWVECVGCADRSAYDLGQHTAATGVRLVAEKRLPAPKTVEVSEIVPNKQALGKTFKK 542
            |.|:.|||||:|||||||||||||..|:..|..:||..::|..|..|...||...|:..|..|:|
Yeast   376 DGELKTSYGWIECVGCADRSAYDLTVHSKKTKEKLVVRQKLDNPIEVTKWEIDLTKKLFGPKFRK 440

  Fly   543 EAKNITDALAKLSLEEITKVEEQLAGDGQY--KLTTADGQSHDLGKDTISVKHSTKTVHVEEFIP 605
            :|..:...|..:|.:::....|.|..:|::  |:...||:. :|....:.::..||..||.|::|
Yeast   441 DAPKVESHLLNMSQDDLASKAELLKANGKFTIKVDGVDGEV-ELDDKLVKIEQRTKVEHVREYVP 504

  Fly   606 SVVEPSFGIGRIMYSLLEHSFQCRDGDEQRCYFTLPPLVAPIKCSILPLSNNTDFQPYTQKLSSA 670
            ||:|||||||||:||:.||||..|..|..|...:.||||||.|..::||||:.|..|.|.:::..
Yeast   505 SVIEPSFGIGRIIYSVFEHSFWNRPEDNARSVLSFPPLVAPTKVLLVPLSNHKDLVPVTTEVAKI 569

  Fly   671 LTKAELSHKVDDSSGSIGRRYARTDEIAIPYGITVDFDTLKEPHTVTLRDRNTMKQVRVGLEEVV 735
            |.|:::..|:|||..|||:||||.||:..|:|:|:||::.|: |:||||:|::.||||..:|.|:
Yeast   570 LRKSQIPFKIDDSGVSIGKRYARNDELGTPFGVTIDFESAKD-HSVTLRERDSTKQVRGSVENVI 633

  Fly   736 GVVKDLSTARTTWESVTEQY-PLFEQQEA 763
            ..::|::....:||..|:.. |...|.||
Yeast   634 KAIRDITYNGASWEEGTKDLTPFIAQAEA 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyRS	NP_730022.1	PLN02734	88..756	CDD:178335	315/670 (47%)
GRS1	NP_009679.2	glyS_dimeric	15..640	CDD:273051	306/626 (49%)