DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and EZR

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001104547.1	Gene:	EZR / 7430	HGNCID:	12691	Length:	586	Species:	Homo sapiens

Alignment Length:	292	Identity:	55/292 - (18%)
Similarity:	108/292 - (36%)	Gaps:	80/292 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QIQKQETAIINGNYE---------HMTVNEFFVQLAQQYKHEQQLQALARENSSILRRKQSTTSR 138
            :|.|:...:..||:|         .:.|.:...| |::.||::||:   |:.....::::.|..|
Human   275 RINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ-AREEKHQKQLE---RQQLETEKKRRETVER 335

  Fly   139 ESRDSQMTINNNNRQSETLSNRSSEYDNYQPSSSAGAGDMLVIGV--------AQQQAQQQPPLV 195
            |.  .||.     |:.|.|..|..:|:.....:.....:.:...:        ||::|::.....
Human   336 EK--EQMM-----REKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADR 393

  Fly   196 KSALKKRPTPTPSQMQYMRQQHQQQAHL-------AMNMNYQRSQPDVISMY-----SANSSNVA 248
            .:||:.:.......:..::.|.|..|.|       |:....:|.:.|.:..:     .|....|.
Human   394 MAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVK 458

  Fly   249 TLRQ--------PPQVAPQQQPIIVQCDKYYLSPTHQSYNEG----GF--------IKSSQNIKK 293
            |..:        ||...|..:|:     .|::..:.|  :||    |:        |:..:|.:|
Human   459 TKEELHLVMTAPPPPPPPVYEPV-----SYHVQESLQ--DEGAEPTGYSAELSSEGIRDDRNEEK 516

  Fly   294 YVSPMASPSNISYEQQQQRNPLHHQRQLDAIS 325
            .::.......:             ||||..:|
Human   517 RITEAEKNERV-------------QRQLLTLS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
EZR	NP_001104547.1	B41	7..206	CDD:214604
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305\|PubMed:25417112	115..120
		FERM_C_ERM	200..296	CDD:270015	5/20 (25%)
		Interaction with SCYL3. /evidence=ECO:0000269\|PubMed:12651155	244..586		55/292 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..341		11/40 (28%)
		ERM	338..586	CDD:395622	39/223 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..564		12/66 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900