DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sstn and nf2a

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001122179.1	Gene:	nf2a / 561184	ZFINID:	ZDB-GENE-080722-7	Length:	593	Species:	Danio rerio

Alignment Length:	297	Identity:	57/297 - (19%)
Similarity:	112/297 - (37%)	Gaps:	68/297 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SEKSWLLQQIQKQETAIINGNYEHMTVNEFFVQLAQQYKHE-------------QQLQALARENS 126
            |:|.:.::.:.|: ..:...|...:.||:..:||... .|:             ||::..|||..
Zfish   266 SDKEFAIKPVDKR-ADVFKFNSSKLRVNKLILQLCIG-NHDLFMRRRRVDSLEVQQMKTQAREEK 328

  Fly   127 SILRRKQSTTSRESRDSQMTINNNNRQSETLSNR------SSEYDNYQPSSSAGAGDMLV--IGV 183
            :   |||....|..|:.|:. .:..|..:.|..|      .:...|.....|....|:|.  ..:
Zfish   329 A---RKQMERQRLEREKQLR-EDAERARDELQRRLIQLQDEAHLANEALLRSEETADLLAEKAQI 389

  Fly   184 AQQQAQQQPPLVKSALKKRPTPTPSQMQYMRQ---QHQQQAHLAMNMNYQRSQPDVISMYSANSS 245
            |:::|:        .|.::......:||.::.   :.:::..|   |..:..:.::|::..|..|
Zfish   390 AEEEAK--------LLAQKAAEAEQEMQRIKVTAIRSEEEKRL---MEQKMLEAEMIALKMAEES 443

  Fly   246 -----NVATLRQPPQVAPQQQ-----PIIVQCDKYYLSPTHQSYN----EG-GFIKSSQNIK--- 292
                 ....|:|..|.|.:.:     .::....|...||...|.|    :| .|..|.:|:.
Zfish   444 ERRAKEADQLKQDLQEARESERRAKNKLLEITSKTEYSPVPLSANSLPADGPNFNFSMENLSFDF 508

  Fly   293 -----KYVSPMASPSNISYEQQQQRNPLHHQRQLDAI 324
                 |.:|.......:.|.::.:    |.|.||:.:
Zfish   509 KDTDMKRLSMEIEKEKVEYMEKSK----HLQEQLNEL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
nf2a	NP_001122179.1	B41	23..221	CDD:214604
		FERM_N	25..85	CDD:286467
		FERM_M	106..221	CDD:278785
		FERM_C_ERM	215..311	CDD:270015	9/46 (20%)
		SKIP_SNW	<323..354	CDD:280827	10/34 (29%)
		GBP_C	<334..462	CDD:303769	24/139 (17%)
		ERM	346..593	CDD:279153	37/211 (18%)
		coiled coil	453..462	CDD:293879	4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900