DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and INAVA

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_060735.4	Gene:	INAVA / 55765	HGNCID:	25599	Length:	663	Species:	Homo sapiens

Alignment Length:	612	Identity:	126/612 - (20%)
Similarity:	193/612 - (31%)	Gaps:	218/612 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EDDPKVRKENLEARK------------QALEQRLSEKSWLLQQIQKQETAIINGNYEHMTVNEFF 105
            |..||||:....|.|            .:||::|:        :|.|.|
Human   161 EKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLA--------LQLQIT---------------- 201

  Fly   106 VQLAQQYKHEQQLQALARENSSILRRKQSTTSRESR--DSQMTINNNNRQSE-------TLSNRS 161
             :.|::...|:.|...||.     :||.|....|.:  :.|..:....|.||       .|....
Human   202 -EAARRLCLEENLSRQARR-----QRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGREL 260

  Fly   162 SEYDNYQPSSSAGAGDMLVIGVAQQQAQQQPPLVKSALKKRPTPTPSQMQYMRQQHQQQAHLAMN 226
            |..|:      :...|.|::...:.|..:.|| ...|...||.| |..::
Human   261 SASDD------SSLSDGLLLEEEESQVPKPPP-ESPAPPSRPLP-PQTLE--------------- 302

  Fly   227 MNYQRSQPDVISMYSANSSNVATLRQPPQVAPQQQPIIVQCDKYYLSPTHQSYNEGGFIKSSQNI 291
             ..|.:.|:      |.|..    |.|.|.:|.::   ...|..|..|.          |||:..
Human   303 -GLQPTGPE------AGSPE----RAPVQNSPWKE---TSLDHPYEKPR----------KSSEPW 343

  Fly   292 KKYVSPMASPSNISYEQQQQRNPLHHQRQLDAISL----APSYVSVDMEAAQHQQQYRWRSQSHI 352
            .:..||..:|         |..|       .|.||    ..||..|.:.....|    |:.::.
Human   344 SESSSPATTP---------QDGP-------SASSLWLLEPASYHVVPIRGVPGQ----WQGRTS- 387

  Fly   353 APLTPPQLGIIEVKSHSSDMLAVPM----P--------PSRYPPHDEISLSSSSTTIEKKPKPKQ 405
            ||.||.    |:.:...|..|.|..    |        |.|.|.|..:::..|.....|.|.|..
Human   388 APATPE----IQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHA 448

  Fly   406 WLES-SLDGPAVIRQMDSQPHSPAGSSNGSSNPGAAAMVSSKP-------RAKLSSQSMSVAGRH 462
            ...| |.|..:.:..: |.|.||     |||:|..:.:....|       .|.:.:.|..:...|
Human   449 ACHSCSEDSGSDVSSI-SHPTSP-----GSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHH 507

  Fly   463 YSMSNQRPTPNYPSASYAVNTSSKALLSQSTSYLNAMEQTLGISVSYPLEPLDIPALRNLPPKPS 527
            ..:  ..|...:|:..|.|...|                        ||.|.:. .||...|.|:
Human   508 PKL--LLPPGYFPAGRYVVVAES------------------------PLPPGEW-ELRRAAPGPA 545

  Fly   528 QMQQPTP-------PPRPPPANQAHTQNQNLSHSGNGSSSGLAHGNAVQTALVSPPVTVATASLS 585
            ..::.||       |.|   :....|.:...|.:|.|.|.                     |::|
Human   546 YEEEGTPLRYQRLVPSR---SRIVRTPSLKDSPAGRGLSK---------------------AAVS 586

  Fly   586 PEI-------RIESPKNMTVVQQATFQ 605
            .|:       |:.|.:..::.:|..|:
Human   587 EELKWWHERARLRSTRPHSLDRQGAFR 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
INAVA	NP_060735.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		DUF3338	87..215	CDD:314652	16/78 (21%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000269\|PubMed:28436939	164..170		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..362		36/182 (20%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000269\|PubMed:28436939	332..338		2/15 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..425		12/55 (22%)
		Nuclear localization signal (NLS) 3. /evidence=ECO:0000269\|PubMed:28436939	422..428		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..493		14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900