DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and MSN

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_011529261.1	Gene:	MSN / 4478	HGNCID:	7373	Length:	610	Species:	Homo sapiens

Alignment Length:	318	Identity:	65/318 - (20%)
Similarity:	126/318 - (39%)	Gaps:	75/318 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QIQKQETAIINGNYE---------HMTVNEFFVQLAQQYKHEQQLQALARENSSILRRKQSTTSR 138
            :|.|:..|:..||:|         .:.|.:...| |::.||::|::....||.   ::|:....:
Human   308 RINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ-AREEKHQKQMERAMLENE---KKKREMAEK 368

  Fly   139 ESRDSQMTINNNNRQSETLSNRSSEYDNYQPSSSAGAGDMLVIGVAQQQAQQQPPLVKSAL---- 199
            |....:       |:.|.|..|..:.:.....             |||:.::|   .:.||
Human   369 EKEKIE-------REKEELMERLKQIEEQTKK-------------AQQELEEQ---TRRALELEQ 410

  Fly   200 -KKRPTPTPSQMQYMRQQHQQ--QAHLAMNMNYQRSQPDV---ISMYSANSSNVATLRQPPQ--- 255
             :||......::...||:.::  :|.|..:.:.:::|..:   ::..:|..|.:...||..:
Human   411 ERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEA 475

  Fly   256 VAPQQQPIIVQCDKYYLSPTHQSYNEGGFIKSSQNIKKYVSP--MASPSNISYEQQQQRNPLHHQ 318
            |..||:..:||.|               ..|:...:|..:|.  :|.|:. :.:.:|..|.....
Human   476 VEWQQKAQMVQED---------------LEKTRAELKTAMSTPHVAEPAE-NEQDEQDENGAEAS 524

  Fly   319 RQL--DAISLAPSYVSVDMEAAQHQQQYRWRSQSHIAPLTPPQLGI-IEVKSHSSDML 373
            ..|  ||::...|......||.:::     |.|.|:..||...... .|.|..::||:
Human   525 ADLRADAMAKDRSEEERTTEAEKNE-----RVQKHLKALTSELANARDESKKTANDMI 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
MSN	XP_011529261.1	B41	40..239	CDD:214604
		FERM_N	42..104	CDD:286467
		FERM_M	124..239	CDD:278785
		FERM_C_ERM	233..329	CDD:270015	6/20 (30%)
		ERM	380..610	CDD:279153	47/235 (20%)
		TMPIT	416..>497	CDD:285135	16/95 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900