DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and Frmd4b

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_038964692.1	Gene:	Frmd4b / 252858	RGDID:	620172	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	119/612 - (19%)
Similarity:	196/612 - (32%)	Gaps:	231/612 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KIEDDPKVRKENLEARKQALEQRLSEKSWLLQQIQKQETAIINGNYEHMTVNEFFVQLAQQYKHE 115
            |:..:|.:.|...:.|||.....:..    ||:|:.             ::||:.::..::...:
  Rat   519 KLASEPDLCKTVKKKRKQDYTDAVKR----LQEIEN-------------SINEYRIRCGKKPSQK 566

  Fly   116 QQL----QALARENSSILRRKQSTTSRESRDS-------------------------------QM 145
            ..:    ..:..|:||:   ..:||..:..||                               :.
  Rat   567 AAVVPPEDIIPSESSSL---SDTTTYDDPNDSFTLAGQRPSSVPHSPRILPPKSLGIERIHFRKS 628

  Fly   146 TINN---NNRQS-ETLSNRSSEYDNYQPSSSAGAGDMLVIGVAQQQAQQQPPLVKSALKKRPTPT 206
            :||.   :.||| |.||..||.|...:.....|           :.....|.|.::|........
  Rat   629 SINEQFVDTRQSREMLSTHSSPYKTLERRPQGG-----------RSMPTTPVLTRNAYSSSHLEP 682

  Fly   207 PSQMQYMRQQH---QQQAHLAMNMN----------YQRSQPDVI----SMYSANSS--------- 245
            .|..|:.||:.   :.|:||...|:          .|||....|    |.|::.||
  Rat   683 DSSSQHCRQRSGSLESQSHLLSEMDSDKPFFTLSKSQRSSSTEILDDGSSYTSQSSSEYYCVTPA 747

  Fly   246 ----------------------------------NVA---TLRQ---------PPQ---VAPQQQ 261
                                              |:|   |||.         ||.   :|  ..
  Rat   748 AGPYYTTQTLDTRARGRRRSKKHSVSTSNSGSMPNLAQKDTLRNGVYSKGQDPPPSGYYIA--GY 810

  Fly   262 PIIVQCDKYYLSPTHQSYNEGGFIKSSQNIKKY-VSP-MASPSNISYEQQQQRNPLHHQRQLD-- 322
            |...:||.||         .||::..:....:| |:| ..|.::..|::|:..:...|:.::|
  Rat   811 PPYAECDLYY---------SGGYVYENDTEGQYSVNPSYQSSAHYGYDRQRDYSRSFHEDEVDRV 866

  Fly   323 -----AISLAPSYVSVDME----------AAQH-----QQQYRWRSQSHIAPLTPPQLGIIEVKS 367
                 |....|...:|..|          .|:|     |:....:.|.| :|.|          |
  Rat   867 PHNPYATLRLPRKAAVKSEHITKNIHKAIVAEHLRGWYQRASGQKDQGH-SPQT----------S 920

  Fly   368 HSSDM----------LAVPMPPSRYPPHDEISLSSSSTTIEKKPKPKQWLESSLDGPAVIRQMDS 422
            ..||.          |.||..||        |.:||.:::........|......|   :.:.::
  Rat   921 FDSDRGSQRCLGFAGLQVPCSPS--------SRASSYSSVSSTNASGNWRTQLTTG---LSEYEN 974

  Fly   423 QPHSPAGSSNGS-SNP--------------GAAAMVSSKPRAKLSSQSMSVAGRHYSMSNQRPT- 471
            ..|||..|..|: .||              .....|:.:.|:.|||...|||.|:.:....|.|
  Rat   975 PVHSPYTSYYGNIYNPLPSPNRHNHNRGPLWQRMAVAPEVRSVLSSVLFSVASRNSTQRALRWTV 1039

  Fly   472 ---PNYPSASYAVNTSSKALLSQSTSY 495
               .::.:|...||..|..:.:.|..:
  Rat  1040 QTETSWKTAWRVVNRGSFGMKTPSPEH 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
Frmd4b	XP_038964692.1	FERM_F1_FRMD4B	57..145	CDD:340720
		B41	75..260	CDD:214604
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012
		DUF3338	395..528	CDD:403120	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900