Protein Alignment sstn and FRMD4B

DIOPT Version :10

• Sequence 1: NP_648745.1
• Gene: sstn / 39643
• FlyBaseID: FBgn0036476
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_016861478.1
• Gene: FRMD4B / 23150
• HGNCID: 24886
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 110/587 - (18%)
• Similarity: 188/587 - (32%)
• Gaps: 234/587 - (39%)

  Fly    51 KIEDDPKVRKENLEARKQALEQRLSEKSWLLQQIQKQETAIINGNYEHMTVNEFFVQLAQQYKHE 115
            |:.::|.:.|...:.|||.....:.:    ||:|:.             .:||:.::..:  |..
Human   519 KLANEPDLCKTVKKKRKQDYTDAMKK----LQEIEN-------------AINEYRIRCGK--KPS 564

  Fly   116 QQLQALAR-----ENSSILRRKQSTTSRESRDS-------------------------------Q 144
            |:...|..     |:||:   ..:||..:..|:                               :
Human   565 QKATVLPEDIIPSESSSL---SDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGIERIHFRK 626

  Fly   145 MTINN---NNRQS-ETLSNRSSEYDNYQPSSSAGAGDMLVIGVAQQQAQQQPPLVKSALKKRPTP 205
            .:||.   :.||| |.||..||.|...:.....|           :.....|.|.::|.......
Human   627 SSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG-----------RSMPTTPVLTRNAYSSSHLE 680

  Fly   206 TPSQMQYMRQQH---QQQAHLAMNMN----------YQRSQPDVI----SMYSANSS-------- 245
            ..|..|:.||:.   :.|:||...|:          .|||....|    |.|::.||
Human   681 PESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRSSSTEILDDGSSYTSQSSTEYYCVTP 745

  Fly   246 ------------------------NVAT--------------LRQPPQVAPQQQPI--------- 263
                                    ||:|              ||.......|:.|.
Human   746 VTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMPNLAQKDSLRNGVYSKSQEPPSSSYYIAGYT 810

  Fly   264 -IVQCDKYYLSPTHQSYNEGGFIKSSQNIKKY-VSP-MASPSNISYEQQQQRNPLHHQRQLDAIS 325
             ..:||.||         .||::..:....:| |:| ..|.::..||:|:..:...|:.::|.:.
Human   811 PYAECDFYY---------SGGYVYENDTEGQYSVNPSYRSSAHYGYERQRDYSRSFHEDEVDRVP 866

  Fly   326 LAPSYVSVDME------------------AAQH-----QQQYRWRSQSHIAPLTPPQLGIIEVKS 367
            ..| |.::.:.                  .|:|     |:....:.|.| :|.|          |
Human   867 HNP-YATLRLPRKAAAKSEHITKNIHKALVAEHLRGWYQRASGQKDQGH-SPQT----------S 919

  Fly   368 HSSDM----------LAVPMPPSRYPPHDEISLSSSSTTIEKKPKPKQWLESSLDGPAVIRQMDS 422
            ..||.          |.||..||        |.:||.:::........|......|   :...::
Human   920 FDSDRGSQRCLGFAGLQVPCSPS--------SRASSYSSVSSTNASGNWRTQLTIG---LSDYET 973

  Fly   423 QPH---------------SPAGSSNGSSNPGAAAMVSSKPRAKLSSQSMSVAGRHYSMSNQRPTP 472
            ..|               ||:..:.|..:|  ..:||.:.|:.::|..:|||    |.:|.:.:.
Human   974 PAHSSYTSCYGNVYNPLPSPSRQNQGLLSP--RMVVSPEVRSVVNSLLLSVA----SCNNTQKSV 1032

  Fly   473 NY 474
            |:
Human  1033 NW 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
FRMD4B	XP_016861478.1	FERM_F1_FRMD4B	57..145	CDD:340720
		B41	75..260	CDD:214604
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012
		CUPID	395..529	CDD:463360	2/9 (22%)