DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and Frmd4a

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_006497499.1	Gene:	Frmd4a / 209630	MGIID:	1919850	Length:	1061	Species:	Mus musculus

Alignment Length:	734	Identity:	155/734 - (21%)
Similarity:	262/734 - (35%)	Gaps:	177/734 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAPKSRNMASLK-DEDQAATTSNSMHNLNNNNNTNNINNNHSSS--SNNNKIEDDPKVRKEN--- 62
            |...:|:::.:. |..:..|...|  .|.|..:...|.:..|.|  |:.::..|..:..|::
Mouse   342 KIHAARSLSEIAIDLTETGTLKTS--KLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLA 404

  Fly    63 -LEARKQALEQRLSEKSWLLQQIQKQETAI---------INGNYEHMTVNEFFVQLAQQYK---- 113
             |::|::|||:.|.::...|:::..:|..:         ::...|...|..   ::...:|
Mouse   405 ALKSRQEALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEPPIVRR---RIGTAFKLDEQ 466

  Fly   114 ------HEQQLQALARE------------------NSSILRRKQSTTS-----RESRDSQMTINN 149
                  .|.:|:.|.||                  |.|...:||..||     ::.::.:..||.
Mouse   467 KILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINE 531

  Fly   150 NN-RQSETLSNRSSEY--DNYQPSSSAGAGDMLV-----------IGVAQQQAQQQPPLVKSALK 200
            |. :..:..:.|:|..  |....|..:...|.||           |...|...:..||...|: .
Mouse   532 NRIKSGKKPTQRASLVIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLQSPHKGLPPRPPSS-H 595

  Fly   201 KRPTPTPSQMQYMRQQHQQQAHLAMNMNYQRSQPDVISMYSANSSNVATLRQPPQVAPQQQPIIV 265
            .|| |.|..::.:||.|..:.      :|.:| |....|:|.:|     |.:|.:...::
Mouse   596 NRP-PPPQSLEGLRQLHYHRT------DYDKS-PLKPKMWSESS-----LDEPYEKVKKR----- 642

  Fly   266 QCDKYYLSPTHQ------SYNEGGFIKSSQNIKKYVSPMASPSNISYEQQQQRNPLHHQRQLDAI 324
              ..:..|.:|:      |..|.|...|.||     ||:.|..:.:.:......|       |..
Mouse   643 --SSHGHSSSHKRFPSTGSCTEAGVSSSLQN-----SPIRSLPHWNSQSSMPSTP-------DLR 693

  Fly   325 SLAPSYV----SVDMEAAQ-HQQQYRWRSQSHIAPLTPPQLGIIEVKSHSSDMLAVPMPPSRY-- 382
            ..:|.||    |||:...: |.....:|.:|.........|| .|..:.|.|...   |.:|.
Mouse   694 VRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLG-SENDTGSPDFYT---PRTRSSN 754

  Fly   383 ---PPHDEISLSSSSTTIEKKPKPKQWLESSL--DGPAVIRQMDSQPHSPAGSSNGSSNPGAAAM 442
               |..|..|.:|.|::....|.......|:|  |.|:..||...|....||:. ||::.|
Mouse   755 GSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGAL-GSASSG---- 814

  Fly   443 VSSKPRAKLSSQSMSVAGRHYSMSNQRPTPNYPSASY-------AVNTSSKALLSQSTSYLNAME 500
              |.|.....|.:.|..|..|..|..:|:..|....|       |.....::|.|....:.:...
Mouse   815 --SMPNLAARSGAASTGGGVYLHSQSQPSSQYRIKEYPLYIEGSATPVVVRSLESDQEGHYSVKA 877

  Fly   501 QTLGISVSYPLEPLDIPALR---------NLPPKPSQMQQPTPPPRPPPANQ------------- 543
            | ...|.||....|...:.|         .|.|..||:.: ||......|:.
Mouse   878 Q-FKTSNSYTAGGLFKESWRGGGDEGDAGRLTPSRSQILR-TPSLGRDGAHDKGSGRAAVSDELR 940

  Fly   544 --------AHTQNQNLSH-SGNGSSSGLAHGNAVQTALVS-------PPVTVATASLSPEIRIES 592
                    :|.::..||| |...|.||..:..:.|:..|:       |.:..||::..|:.:..|
Mouse   941 QWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSS 1005

  Fly   593 PKNMTVVQQATFQPYKEVT 611
            ..:..:.......|:..:|
Mouse  1006 TPSSEIGATPPSSPHHILT 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
Frmd4a	XP_006497499.1	FERM_F1_FRMD4B	33..121	CDD:340720
		B41	36..236	CDD:214604
		FERM_C_FRMD4A_FRMD4B	232..342	CDD:270012	155/734 (21%)
		DUF3338	371..505	CDD:371743	23/136 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900