DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sstn and frmd4ba

DIOPT Version :9

Sequence 1:	NP_648745.1	Gene:	sstn / 39643	FlyBaseID:	FBgn0036476	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_009300910.2	Gene:	frmd4ba / 100333566	ZFINID:	ZDB-GENE-130412-1	Length:	1028	Species:	Danio rerio

Alignment Length:	709	Identity:	132/709 - (18%)
Similarity:	234/709 - (33%)	Gaps:	203/709 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 APKSRNMASLKDEDQAATTSNSMHNLNNNNNTNNINNNHSSSSNNNKIEDDPKVRKENLEARKQA 69
            ||::..:.|::.:|:....||.  :|.::|:.:|..|.........:::|..:..|:.|..:::.
Zfish   385 APRNSKLVSMESKDKLIMASNG--SLVSSNSADNDVNEEQKKEKIAELKDKQEKIKQILALKEEE 447

  Fly    70 LEQRLSEKSWLLQQIQKQETAIING-----------------------------NYEH-MTVNEF 104
            |::....::.|...:.| |..:.:|                             |.|. ..:.:.
Zfish   448 LKKMCLREAELTGVLPK-EFPLASGEKPPTIRRRVGTAFKLDDLFPYDADPCLRNLESCFALQKK 511

  Fly   105 FVQLAQQYKHEQQL----QALARENSSILRRKQSTTSRESRDSQMTINNNNRQS----------- 154
            .|:.|::..||.:|    :...|.|.....:|......|..|.::.|.....|.
Zfish   512 IVEAARKLAHENELGKTVKKKRRRNLLDATKKLQAIENEINDYRVKIGKEPTQRASVIIADDVNL 576

  Fly   155 ETLSNRSSEYDNYQPSSSAGAGDMLVIGVAQQQAQQQPPLVKSALKKRPTPTPSQMQYMRQQHQQ 219
            ::||: ....|:.:||..           .:.::.|..||..|:.....:....|:.:....:..
Zfish   577 DSLSD-CLNLDDDEPSQR-----------QRSRSVQYSPLPNSSGSFTASYHSDQLDHANDDYSN 629

  Fly   220 QAHLAMNMNYQRSQPDVISMY-SANSSNVATLRQP-------------PQVAPQQQPIIVQCDKY 270
            .:.|    ||...|..|..:: .|.|::.:..|||             ||: |:.....:|....
Zfish   630 CSRL----NYAEVQEPVAYIHEDALSTHSSPYRQPLRQPSDSRSMPPTPQL-PRNAYSSIQLSTL 689

  Fly   271 YLSPTHQSYNEGGFIKSSQ-------------NIKKYV---SPMASPSNISYEQQQQRNPLHHQR 319
            |...:....::..|:..|:             |..:.:   |...|.|::.|.....|....|:|
Zfish   690 YRQRSGSLESQSQFLTESEPSEPVFISAPRRSNSTELLDDGSSYTSQSSVEYSAPHSRAKNRHRR 754

  Fly   320 QLDAI--------SLAPSYVSVDMEAAQHQQ----QYRWRSQSHIAP-LTP--PQLGIIEVKSH- 368
            :...|        :||.:.....:..:||.|    .|......:|.| :.|  |.:...|::.|
Zfish   755 RQGNIYANTGSMPNLAQNDTRGYISQSQHPQTTTAYYVTGYPRYIEPEVYPNGPYMYESEMEGHY 819

  Fly   369 -----------------------SSDMLAVPMPPSRYPPHDEISLSSSSTTIE------------ 398
                                   |.::.|...||...||....:|..:....|
Zfish   820 NVNPSYHRHEPHGNYAQDEMDGLSHNLYATLRPPRNRPPSRNENLVKNMQRAEVVEHLRGWYNRQ 884

  Fly   399 KKPK-------PKQWLESSLDGPAVIRQMDSQPHSPAGSSNGSSNPGAAAMVSSKPRAKLSSQSM 456
            .||:       |:|.|.......:.:|...:..:|..||.|....|..|          :|...|
Zfish   885 HKPQGYDAYRAPQQSLNYRTMSTSYVRSDSTASYSTVGSGNWHGRPVMA----------MSEYEM 939

  Fly   457 SVAGRHYSMSNQRPTPNYPSASYAVNT--SSKALLSQSTSYLNAMEQTLGISVSYPLEPLDIPAL 519
            .:|  |:.             ||..||  .|..|.|.                |:|......||.
Zfish   940 PLA--HHQ-------------SYGYNTVHHSHPLHSS----------------SHPKRAWHCPAS 973

  Fly   520 -RNLPPKPSQMQQPTPPPRP-PPANQAHTQNQNLSHSG-NGSSSGLAHGNAVQTALVSP 575
             :...|:.||....:.|||| ||::..:...|    :| :...:|.|..|....|..||
Zfish   974 PQYYHPRFSQACSSSLPPRPLPPSSSCYQMKQ----TGLSAPQTGGARVNKASFAKCSP 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sstn	NP_648745.1	None
frmd4ba	XP_009300910.2	B41	61..260	CDD:214604
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012
		DUF3338	395..527	CDD:314652	22/134 (16%)
		DMP1	<586..750	CDD:311295	31/179 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900