DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and SYTL5

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001156806.1	Gene:	SYTL5 / 94122	HGNCID:	15589	Length:	752	Species:	Homo sapiens

Alignment Length:	695	Identity:	149/695 - (21%)
Similarity:	230/695 - (33%)	Gaps:	231/695 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 GSVSDSCDLPTDSEEVAIAKECQPIQP-----------ASQLHGMHGGMGLNH--HHMGTVSATG 152
            |.:.|..| |..:..:.:.:||:...|           .:||..:.|......  .....|:..|
Human    72 GLIFDRGD-PCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLG 135

  Fly   153 TDILR--------GPAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSR--------HSG 201
            ||::|        |..||     ....|:|....:...:|....::|.| .|.|        .|.
Human   136 TDVVRQSILRRSPGAEEV-----QSQEQTRQDAEKSDTSPVAGKKASHD-GPKRKGFLLSKFRSA 194

  Fly   202 HRGS--SPQIRTFGPDGRS-----------SLPSEPGFPHHLARS-------PSPMRTISLDARC 246
            .||.  :|:..|    |||           ||.|.||.......|       |.|....|
Human   195 TRGEIITPKTDT----GRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKS----- 250

  Fly   247 GSPAHSADPGDLRTPSPS----------------QSSLASLAGGSGMGGSSAGKGVAG------- 288
             |.::...||...:|:||                ...||::.|.|.....|..:..:|
Human   251 -SRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVS 314

  Fly   289 GRCLS--------------------PLLIPPRSQPG-------------VDPAMGPASPLGALQP 320
            |..||                    .:.|..:|.||             :|..:.     ..|..
Human   315 GTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVS-----SQLST 374

  Fly   321 DLYRMPDGP------------VYLTAPESS----------------------HAVGRLHLRVKYD 351
            :.:|:..|.            .||..|::.                      ...|.:.|.:.|.
Human   375 NTHRLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVSGEILLHISYC 439

  Fly   352 YHLFDLTVHLIEAHNLSPIEEGGFR-DPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFKFPV 414
            |....|.:.:....||:..:|...| |.||:..|.|:.. :.||:|.|..| :||.|::..|:.:
Human   440 YKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTG-TNPEFNETLKYTI 503

  Fly   415 SRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDLLRTKKPKED-------- 471
            |..||:.:.|.|.|..|||:..|..:|||.|..|..:.....:.|..|    :||.:
Human   504 SHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVL----QPKVEFAPDIGLQ 564

  Fly   472 -RPELLCSLNYLPQAER-----------------------------LTVVIMKARNLDTLQ---- 502
             :.||...|.|:|..|.                             |.|.|.:|:||..::
Human   565 YKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGT 629

  Fly   503 -EPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFN-LQSNYLHNAAIEIYVVGAGSEAT 565
             :.:||.||:.:..:..|.||.:.|..  .||.||..|.|: :....:.|..:|:.:....:.::
Human   630 SDSFVKGYLLPDDSKATKHKTLVIKKS--VNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSS 692

  Fly   566 EIGCCGLGPQESGTGCQH----------------WHDMINNARKP 594
            .|...|: ...||:|..|                |..|.||...|
Human   693 NIFLGGV-RLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTP 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	39/123 (32%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	39/173 (23%)
SYTL5	NP_001156806.1	PHD_SF	11..123	CDD:328929	10/51 (20%)
		FYVE_Slp5	62..108	CDD:277305	7/36 (19%)
		CEP170_C	<159..>309	CDD:317681	35/160 (22%)
		C2A_SLP-4_5	429..552	CDD:175995	40/127 (31%)
		C2B_SLP_1-2-3-4	566..744	CDD:175987	39/174 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810