Protein Alignment Sytbeta and SYTL4

DIOPT Version :9

• Sequence 1: NP_648734.1
• Gene: Sytbeta / 39630
• FlyBaseID: FBgn0261090
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_001357091.1
• Gene: SYTL4 / 94121
• HGNCID: 15588
• Length: 676
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 124/570 - (21%)
• Similarity: 204/570 - (35%)
• Gaps: 149/570 - (26%)

  Fly   151 TGTDILR-----GPA-----EVFHSPLHLHHQSRSFPPR-----LQRTPSISSQSSVDSAPSRHS 200
            ||::|:|     .||     .|..|.||.......:|.|     .|:.||:..:  |....|..|
Human   131 TGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFE--VPKLKSGKS 193

  Fly   201 GHRGSSPQIRTFGPDG-----RSSLPSEPGFPHHLARSPSPMRTISLDARCGSP-AHSADPGD-- 257
            .....|..:.:|..|.     |.||.....||.....| :|...:..:.:.|.. ....|.|:
Human   194 ALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMS-APKSQVEKETQPGGQNVVFVDEGEMI 257

  Fly   258 -------LRTPSPSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAM------ 309
                   :..||....|:..|.....:..|    |..|.|        .:|.||::..|
Human   258 FKKNTRKILRPSEYTKSVIDLRPEDVVHES----GSLGDR--------SKSVPGLNVDMEEEEEE 310

  Fly   310 ----------------------GPASPLGALQPDLYRMPD-GPVYLTAPESSHAVGRLHLRVKYD 351
                                  ...|.:|::........| |.:::|        ||:...:||:
Human   311 EDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVT--------GRIAFSLKYE 367

  Fly   352 YHLFDLTVHLIEAHNLSPIEEGGFR-DPYVRLMLQPEVDSR-KRQTHIHRGESNPYFDQHFKFPV 414
            .....|.||:.|.|.|:..:|...| :|||:..|.|:...: ||:|.|.|...||.:|:..::.:
Human   368 QQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEI 432

  Fly   415 SRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVE----IWGDLLRTKKP---KEDR 472
            ....|..:.|...|..:.|:..|..:||..|.:|...|.|.::    :.|. :..:.|   ...:
Human   433 PESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGK-ISAESPTGLPSHK 496

  Fly   473 PELLCSLNYLPQAE----------------RLTVVIMKARNLDTLQ-----EPYVKIYLIQNGKR 516
            .||:.||.|:|.::                .|.|.|.:|:||...:     :.:||.||:....:
Human   497 GELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNK 561

  Fly   517 IKKKKTSITKSDDPTNPIWNEAFTFN-LQSNYLHNAAIEIYV----------------VGAGSEA 564
            ..|:||.:.|.  ..||.:|..|.:| ::...|.:..:|:.|                :|.|:..
Human   562 ASKRKTPVMKK--TLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTVN 624

  Fly   565 TE----------------IGCCGLGPQESGTGCQHWHDM-INNARKPTAM 597
            .:                ..|..:...:....||..|:: .....|||.|
Human   625 IQPILIECLLCARTRGRLSSCTDMCTDKCDPDCQELHNLPTKKIYKPTYM 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	37/127 (29%)
		C2B_Synaptotagmin	473..601	CDD:175975	38/180 (21%)
SYTL4	NP_001357091.1	FYVE_2	8..121	CDD:308117
		FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..243		10/44 (23%)
		C2A_SLP-4_5	357..481	CDD:175995	37/131 (28%)
		C2B_SLP_1-2-3-4	496..>622	CDD:175987	29/127 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810