Protein Alignment Sytbeta and DOC2A

DIOPT Version :10

• Sequence 1: NP_648734.1
• Gene: Sytbeta / 39630
• FlyBaseID: FBgn0261090
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_003577.2
• Gene: DOC2A / 8448
• HGNCID: 2985
• Length: 400
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 107/414 - (25%)
• Similarity: 169/414 - (40%)
• Gaps: 88/414 - (21%)

  Fly   229 HLARS--PSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGVAGGRC 291
            |:|.:  |.|:|          |.........|.|.|.        ||.|.||.:...
Human    16 HMAINVCPGPIR----------PIRQISDYFPRGPGPE--------GGGGGGGEAPAH------- 55

  Fly   292 LSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDG-PVYLTAPESSHAVGRLHLRVKYDYHLF 355
            |.||.:.|           ||:.|||..|:     || .|.....:.:.|:|.|...:.||....
Human    56 LVPLALAP-----------PAALLGATTPE-----DGAEVDSYDSDDATALGTLEFDLLYDRASC 104

  Fly   356 DLTVHLIEAHNLSPIEEGGFRDPYVRLMLQP-EVDSRKRQTHIHRGESNPYFDQHFKFP-VSRDQ 418
            .|...::.|..|.|::..|..||||:|.|.| ...:.|.:|...|...||.:::...:. ::.|.
Human   105 TLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDD 169

  Fly   419 LQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSK--------------------SVEIWG--- 460
            :..|.|.:.|.|.|:.|||:.|||:|:.:..|..|:                    |..:.|
Human   170 ITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISC 234

  Fly   461 ---DLLRTKKPK---EDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNG 514
               :|.:.::.:   |:|..:|.||:|..:...|.|.|::..:|..:     .:||||.||..:.
Human   235 YLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDV 299

  Fly   515 KRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEI----YVVGAGSEATEIGCCGLGPQ 575
            .:..|.||.:.|.  ..||.:||.|.:.::.:.|....:|:    |.:|..::.  ||...|||.
Human   300 DKKSKHKTCVKKK--TLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDF--IGGVSLGPG 360

  Fly   576 ESGTGCQHWHDMINNARKPTAMWH 599
            ..|...:||.|.:.........||
Human   361 ARGEARKHWSDCLQQPDAALERWH 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	PHA03307	39..>267	CDD:223039	9/39 (23%)
		C2	341..463	CDD:472691	38/149 (26%)
		C2B_Synaptotagmin	473..601	CDD:175975	38/136 (28%)
DOC2A	NP_003577.2	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9804756	1..89		27/113 (24%)
		C2A_Rabphilin_Doc2	90..213	CDD:176000	36/122 (30%)
		Interaction with UNC13D. /evidence=ECO:0000269|PubMed:18354201	215..400		43/174 (25%)
		C2B_Rabphilin_Doc2	254..386	CDD:176030	38/135 (28%)