DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Doc2b

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_112404.1	Gene:	Doc2b / 81820	RGDID:	620519	Length:	412	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	117/444 - (26%)
Similarity:	176/444 - (39%)	Gaps:	82/444 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 TPSISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSE--PGFPHHLARSPSPMRTISLDAR 245
            |.||....::|..|                ||.......|:  |.||..|..:.:|..:...||.
  Rat    11 TISIQEHMAIDVCP----------------GPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAP 59

  Fly   246 CGSPAHSADPGDLRTPS----PSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVD 306
            ..|||.:|.|   |:||    .....:..|.|..|..                    |...||..
  Rat    60 ARSPAATAGP---RSPSDGARDDDEDVDQLFGAYGAS--------------------PGPSPGPS 101

  Fly   307 PAMGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIE 371
            |...||.|     |:  ..||...|  ..:...|:|.|...:.||.....|...:.:|..|.|::
  Rat   102 PVRPPAKP-----PE--DEPDADGY--ESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMD 157

  Fly   372 EGGFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFK-FPVSRDQLQGKELILQVLDYDRY 434
            ..|..||||:|.|.|... :.|.:|...|...||.:::... :.::.:.:..|.|.:.|.|.|::
  Rat   158 HNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKF 222

  Fly   435 SHNDIIGEVRISVDGLD----------LSKSVEIWGDLLRTKKPKEDRPELLCSLNYLPQAERLT 489
            .||:.|||.|:.:..|.          |.|.:.:  |....|. .|:|..:|.||.|..|.:.|.
  Rat   223 RHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPV--DKAEDKS-LEERGRILISLKYSSQKQGLL 284

  Fly   490 VVIMKARNLDTL-----QEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLH 549
            |.|::..:|..:     .:||||.||..:..:..|.||::.|.  ..||.:||.|.:.::...|.
  Rat   285 VGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKK--TLNPEFNEEFCYEIKHGDLA 347

  Fly   550 NAAIEI----YVVGAGSEATEIGCCGLGPQESGTGCQHWHDMINNARKPTAMWH 599
            ...:|:    |.:|..::.  ||...||....|...:||.|.:.|..|....||
  Rat   348 KKTLEVTVWDYDIGKSNDF--IGGVVLGINAKGERLKHWFDCLKNKDKRIERWH 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	36/133 (27%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	40/136 (29%)
Doc2b	NP_112404.1	Mediates interaction with DYNLT1. /evidence=ECO:0000250	1..90		25/97 (26%)
		Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250	1..36		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123		29/116 (25%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	33/122 (27%)
		Mediates interaction with STXBP3. /evidence=ECO:0000250	257..375		36/122 (30%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	40/135 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910