DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Pla2g4d

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001019308.1	Gene:	Pla2g4d / 78390	MGIID:	1925640	Length:	825	Species:	Mus musculus

Alignment Length:	233	Identity:	60/233 - (25%)
Similarity:	97/233 - (41%)	Gaps:	37/233 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 LTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQHFKFPVSRDQLQG 421
            |||.::||.:|...:.....||||.:.| |.....|.:|......|:|.:::.|.|.:   |.|.
Mouse    33 LTVKILEARSLPRADLLSQADPYVTVQL-PTASGMKFKTQTVTNSSHPVWNETFSFLI---QSQV 93

  Fly   422 KELI-LQVLDYDRYSHNDIIGEVRISVD----GLDLSKSVEIWGDLLRTKKPKEDRPELLCSLNY 481
            |.:: |.:.|.|..:.:||..:|...|.    |..|.|:..     |..:.|:|...|||....:
Mouse    94 KNILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFS-----LNPQGPEELDVELLMERTW 153

  Fly   482 LPQAERLTVVIMKARNLDTLQEPYVKIYLIQN-----GKRIKKKKTSITKSDDPTNPIW-NEAFT 540
            .|....:|..::.||.|..|.   |.:....|     |:...:.:..:..|.:.|...: :.|||
Mouse   154 DPPENLITNNVLVARELSHLD---VSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFT 215

  Fly   541 FNLQSNYLHNAAIEIYVVGAGSEATEIGCCGLGPQESG 578
            |:..           |:.|   :.||:.....||:.||
Mouse   216 FSFH-----------YMRG---QDTELNGYLRGPRNSG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	31/110 (28%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	26/112 (23%)
Pla2g4d	NP_001019308.1	C2_cPLA2	32..151	CDD:176001	37/126 (29%)
		Patatin_and_cPLA2	278..814	CDD:299702
		PLAc	283..758	CDD:214474
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q86XP0	339..340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900