DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and syt3

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001186849.1	Gene:	syt3 / 779540	XenbaseID:	XB-GENE-956378	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	141/486 - (29%)
Similarity:	220/486 - (45%)	Gaps:	85/486 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 HGMHGGMGLNHHHMGTVSATGTDILRGPAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAP 196
            ||.||  .|:|.|.|.:.|...::  ||    ..|...:....|:|....:....|....|||.|
Frog    98 HGHHG--HLHHSHYGDLLADRVEL--GP----EMPERSYLDMDSYPETNIKISQTSPDIPVDSQP 154

  Fly   197 SRHS--GHRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLR 259
            .:.|  .:..|..|:....|...:        |.::|                 ||:.|......
Frog   155 PKESQIPYAQSHQQVANIAPANVA--------PANVA-----------------PANVAPANRYS 194

  Fly   260 T-PSPSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLY 323
            | |.|....|:|                            |.....||.....|:.:|.::|:||
Frog   195 TLPRPMTQQLSS----------------------------PDFSGHVDEKPEQATSIGQIKPELY 231

  Fly   324 RMPDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEV 388
            :.......:...|:: :.||:...::|.|:...|.|.:::|..|...:..||.||||::.|.|:
Frog   232 KQRSADAEMKKQEAT-SCGRISFILRYAYNSEQLVVKILKALELPAKDANGFSDPYVKMYLLPD- 294

  Fly   389 DSRKRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLS 453
            ..:|.||.:||...||.|::.|.|.|..::||.::|...:.|:||:|.:|:||:|.:. :.|:.|
Frog   295 RKKKFQTKVHRKTLNPIFNETFHFNVPFNELQNRKLHFSIYDFDRFSRHDLIGQVVLD-NLLEFS 358

  Fly   454 KSVE---IWGDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYL 510
            .:.:   ||.|:|.....|.|..|:..||.|||.|.|||..|:||.||..:     .:||||..|
Frog   359 NATDETPIWRDILEASSEKADLGEINFSLCYLPTAGRLTATIIKATNLKAMDLTGFSDPYVKASL 423

  Fly   511 IQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYV-----VGAGSEATEIGCC 570
            |..|:|:||:||||.|  :..||.:|||..|::.:..:.:.::.|.|     :|...   .||.|
Frog   424 ICEGRRLKKRKTSIKK--NTLNPTYNEALVFDIPNENMDHVSLTIAVMDYDCIGHNE---VIGMC 483

  Fly   571 GLGPQESGTGCQHWHDMINNARKPTAMWHYI 601
            .:|......|.:||::|:.|.|||...||.:
Frog   484 RVGSDADMQGREHWNEMLANPRKPIEHWHQL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	43/124 (35%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	53/137 (39%)
syt3	NP_001186849.1	C2A_Synaptotagmin-1-5-6-9-10	248..372	CDD:176031	43/125 (34%)
syt3	NP_001186849.1	C2B_Synaptotagmin-3-5-6-9-10	381..514	CDD:176048	53/137 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920