DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Tc2n

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001076445.1	Gene:	Tc2n / 74413	MGIID:	1921663	Length:	489	Species:	Mus musculus

Alignment Length:	555	Identity:	107/555 - (19%)
Similarity:	187/555 - (33%)	Gaps:	141/555 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SASSVTSTTSGIGSVSAGSVSD--SCD-------LPTDSEEVAIAK---ECQPIQPASQLHGMHG 136
            |||| :..|.||..:::..|..  .|:       ||.|.:||....   :...|||.:|
Mouse    32 SASS-SQNTIGIPPLTSVLVKPQVGCNEDYLLSKLPCDGKEVQFVVPRFKLSYIQPRTQ------ 89

  Fly   137 GMGLNHH---HMGTVSATGTD--------ILRGPAEVFHSPLHLHHQSRSFPPRLQR--TPSISS 188
              |:..|   ..|:..|:..|        ...||:...::|.:::   :.|.|.|.|  .|...:
Mouse    90 --GIPSHLDELEGSARASFGDQKTELCSSFYHGPSYDVYNPCYMY---QHFSPDLSRRFLPHCET 149

  Fly   189 QSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCGSPAHSA 253
            :...           ||...:||      |.||                         ||...|.
Mouse   150 KQLY-----------GSVCDLRT------SKLP-------------------------GSSGLSK 172

  Fly   254 DPGDLRTPS----PSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASP 314
            ...||.|.|    ....|.:|:...|....:|.|                 |...:|.
Mouse   173 SMLDLTTSSQRFIQRHDSFSSVPSSSSSRKNSQG-----------------SNRSLDT------- 213

  Fly   315 LGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLS-PIEEGGFRDP 378
                             :|.......:|||::::.|:.....:.:.:::..::| |...|.....
Mouse   214 -----------------ITLSGDERDLGRLNVKLFYNSSAEQIWITVLQCRDISWPSSYGDTPTI 261

  Fly   379 YVR--LMLQPEVDSRKRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIG 441
            .::  |.|...|..:   :....|.:...|.:.|.|.:....||...|..::  ..:......||
Mouse   262 SIKGILTLSKPVHFK---SSAKEGSNAIEFMETFVFAIKLQNLQAVRLAFKI--QTQTPKKKTIG 321

  Fly   442 EVRISVDGLDLSKSVEIWGDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTLQEP-- 504
            |..:|:..|. ::.:|...:::...|....:.||.....:.....|:.:.|::|:.|.:...|
Mouse   322 ECSLSLRTLS-TQEMEYSLEIIAPSKISVCQAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLT 385

  Fly   505 ---YVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNL-QSNYLHNAAIEIYVVGAGSEAT 565
               :||:.:..:|:.|.||||.:.|:.. ....|.|...|.| |:.......|::|...:.....
Mouse   386 LSFFVKVGMFSSGELIYKKKTRLLKASS-GRVKWGETMIFPLIQTEKEIVFLIKLYSRSSVRRKH 449

  Fly   566 EIGCCGLGPQESG-TGCQHWHDMINNARKPTAMWH 599
            .:|...:....:. .....|.:.|.|..|....||
Mouse   450 FVGQLWISEDSNNIEAVNQWKETITNPEKVVIKWH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	23/124 (19%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	30/134 (22%)
Tc2n	NP_001076445.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..214		7/65 (11%)
		C2A_Tac2-N	239..341	CDD:176066	19/107 (18%)
		C2B_Tac2-N	352..486	CDD:176074	30/134 (22%)
		Nuclear localization signal	446..448		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900