DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and SYT5

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_003171.2	Gene:	SYT5 / 6861	HGNCID:	11513	Length:	386	Species:	Homo sapiens

Alignment Length:	306	Identity:	115/306 - (37%)
Similarity:	182/306 - (59%)	Gaps:	26/306 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 SPLGALQPDLYRM---PDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGG 374
            |.:..:||::..:   |.||....|  ..|.:|||...:.||:....|.|.:::|..|:.::.||
Human    80 SYIDKVQPEVEELEPAPSGPGQQVA--DKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGG 142

  Fly   375 FRDPYVRLMLQPEVDSRKR-QTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHND 438
            ..|||||:.|.|  |.|:| :|.:||...||:|.:.|.|.|...:|.|:.|::.|.|:||:|.||
Human   143 SSDPYVRVYLLP--DKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRND 205

  Fly   439 IIGEVRISVDGLDLSKSVEIWGDLLRTKKPKEDRPEL--LC-SLNYLPQAERLTVVIMKARNLDT 500
            .|||||:.:..:||.:.|:.|.:|  ...|:|::.:|  :| ||.|:|.|.:|||::::|:||..
Human   206 AIGEVRVPMSSVDLGRPVQAWREL--QAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKK 268

  Fly   501 -----LQEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYVVG- 559
                 |.:||||::|:|.||:::||||:|.|  :..||.:||||:|.:..:.:....:|:.|:.
Human   269 MDVGGLSDPYVKVHLLQGGKKVRKKKTTIKK--NTLNPYYNEAFSFEVPCDQVQKVQVELTVLDY 331

  Fly   560 ---AGSEATEIGCCGLGPQESGTGCQHWHDMINNARKPTAMWHYIR 602
               ..:||  ||...:|....|.|.:||.||:.|.|:|.|.||.:|
Human   332 DKLGKNEA--IGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLR 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	49/122 (40%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	54/139 (39%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	50/125 (40%)
		C2	240..374	CDD:387358	54/137 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820