DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Syt9

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_068689.2	Gene:	Syt9 / 60510	MGIID:	1926373	Length:	491	Species:	Mus musculus

Alignment Length:	302	Identity:	108/302 - (35%)
Similarity:	162/302 - (53%)	Gaps:	28/302 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 LGALQPDLYRM-----PDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGG 374
            :|.::|:||:.     .||     ...:|.|.|:|:..:|||..|..|.|.:.:|.||...:..|
Mouse   195 IGRIKPELYKQRSLDNDDG-----RRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSG 254

  Fly   375 FRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDI 439
            ..||||::.|.|: ...|.||.:||...||.||:.|.|||..:.|:.::|...|.|:||:|.:|:
Mouse   255 TSDPYVKIYLLPD-RKTKHQTKVHRKTLNPVFDEVFLFPVHYNDLEARKLHFSVYDFDRFSRHDL 318

  Fly   440 IGEVRIS--VDGLDLSKSVEIWGDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL- 501
            ||:|.:.  .|..|..:...:|.|:........|..||:.||.|||.|.|||:.|:|||||..:
Mouse   319 IGQVVVDHFFDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMD 383

  Fly   502 ----QEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYV----- 557
                .:||||:.|:.:|:|:||:|||..:  :..||::|||..|::....:....:.|.|
Mouse   384 ITGASDPYVKVSLMCDGRRLKKRKTSTKR--NTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDR 446

  Fly   558 VGAGSEATEIGCCGLGPQESGTGCQHWHDMINNARKPTAMWH 599
            ||...   .||.|.:|.:....|..||.:|::..|||.|.||
Mouse   447 VGHNE---VIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWH 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	46/123 (37%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	53/137 (39%)
Syt9	NP_068689.2	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	9..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..147
		C2	221..345	CDD:387358	46/124 (37%)
		C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	53/137 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780