DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and si:ch211-266g18.6

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_005169912.1	Gene:	si:ch211-266g18.6 / 565707	ZFINID:	ZDB-GENE-131121-599	Length:	1009	Species:	Danio rerio

Alignment Length:	524	Identity:	117/524 - (22%)
Similarity:	194/524 - (37%)	Gaps:	143/524 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QPIQPASQLHGMHG-GMGLNHHHMGTVSA-TGTDILRGPAEVFHSPLHLHHQSRSFPPRLQR--- 182
            :||:||.....:.| |...:...:...|| |.:|:|...         |....::.||.||.
Zfish   538 EPIKPAHPSDDVAGFGQDSSEIKVDVDSAETKSDVLLNV---------LARAQKTRPPVLQNITN 593

  Fly   183 -----------TPSISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSP 236
                       .|||....|....|:...|::             |.:|..|.......|::||.
Zfish   594 QEPNLEGTDDTVPSIVIVPSESPDPAEMKGNK-------------RGALVLEALLQSSTAKNPSY 645

  Fly   237 MRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRS 301
            :    .||......:|.|         ..:||:|.  ||.:   |:.||.:.    |.|.:..|:
Zfish   646 I----ADAWEDEGVNSDD---------DDTSLSSY--GSDL---SSRKGFSA----SALSLTDRT 688

  Fly   302 QPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPE--SSHAVGRLHLRVKYDYHLFDLTVHLIEA 364
                          |:|.         .||..|.:  :....|.:...|.|. .:.:|.:.:.:.
Zfish   689 --------------GSLL---------SVYSDAGDFGTVEVQGSVEFAVMYS-PVGELIIMIEQC 729

  Fly   365 HNLSPIEEGGFR-DPYVRLMLQPEVDSR-KRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQ 427
            .:|:.......| ||||:..|.|:...| ||:|.|.:...||.|.:..::.|:|::|..|.|.|.
Zfish   730 QDLAIANPRKQRTDPYVKTYLYPDKSRRSKRKTTIKKRTVNPVFVESLRYKVNREELPEKSLNLS 794

  Fly   428 VLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDL----LRTKKPKEDRPELLCSLNYLPQAE-- 486
            |...|....|..:|:|.:|....|.......|.:|    ....:.||....|..||.|:|.|.
Zfish   795 VWHNDSRGRNVFLGQVELSFRTWDWGHEALTWYNLQPKTSENAETKESNGLLSVSLKYVPSASTG 859

  Fly   487 -------RLTVVIMKARNLDTLQ----EPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFT 540
                   .:.|.:.:|:.|..|:    :.:||.|::.:.::..::||.:.|...  :|::|.|..
Zfish   860 GSKSSTGEIHVWLREAKELRRLKPQGVDSFVKCYILPDTRKKSRQKTRVVKKTQ--DPVYNHAMV 922

  Fly   541 FNLQSNYLHNAAIEIYVVGAGSEATEIGCCGL--------------GPQES-GTGCQH-----WH 585
            :            :.:..|..:||    ||.|              |.:.| |||..:     |.
Zfish   923 Y------------DGFKTGEVTEA----CCELTVWDHNTLANQFLGGVRLSLGTGQSYGKKVDWM 971

  Fly   586 DMIN 589
            |.::
Zfish   972 DSVD 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	35/127 (28%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	32/150 (21%)
si:ch211-266g18.6	XP_005169912.1	C2A_SLP-1_2	707..830	CDD:176039	34/123 (28%)
si:ch211-266g18.6	XP_005169912.1	C2B_SLP_1-2-3-4	843..999	CDD:175987	32/151 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900