DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and Syt7

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_030106854.1	Gene:	Syt7 / 54525	MGIID:	1859545	Length:	719	Species:	Mus musculus

Alignment Length:	727	Identity:	191/727 - (26%)
Similarity:	293/727 - (40%)	Gaps:	156/727 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PAA----CWLAHKRIESWS-----RMAKER----VGAVRRVTLD--------------------R 37
            |||    .|.:.:.:..|.     |.|..|    |.|:..|:|.                    :
Mouse    18 PAAQGQRVWRSEELLSPWEPGSALRGAPTRDVLLVSAIITVSLSVTIVLCGLCHWCQRKLGKRYK 82

  Fly    38 NSADE-GTP-SGSGASSTAG---------GNGVSVVHILPIGEGSTTPPPQ------PMTP--PP 83
            ||.:. ||| ||.|......         .|..|.|.    .:.|:.||.:      |..|  .|
Mouse    83 NSLETVGTPDSGRGRGEKKAINDLDRDFWNNNESTVQ----QKWSSYPPKEFILNISPYAPYGDP 143

  Fly    84 ---------SASSVTSTTSGIGSVSAGSVSDS-CDLPTDSEEVAIAKECQPIQPAS--------- 129
                     |.:.|.:..:|:.....|.:.:. ..:|...|:...:....|.:|.|
Mouse   144 RLSLNGTLLSGAKVATAAAGLAVEREGRLGEKPAPVPPPGEDALRSGGAAPSEPGSSGKAGRGRW 208

  Fly   130 ---QLHGMHGGMGLNHHHMGTVSATGTDILRGPA----------------EVFHSPLHLHHQSRS 175
               |.|...|.:.|::....|:| |.|.:...|:                :....||..:.|.|.
Mouse   209 RMVQSHLAAGKLNLSNFEDSTLS-TATTLESIPSSAGEPKCQRPRTLMRQQSLQQPLSQNQQGRQ 272

  Fly   176 FPPRLQRTPSISS-QSSVDSAP-------SRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHHLAR 232
             |.:...:.|:.. |:...|||       .|....:|:|...:.....|||.  |.||...|:..
Mouse   273 -PSQPTTSQSLGQLQAHAASAPGSNPRAYGRGQARQGTSAGSKYRAAGGRSR--SNPGSWDHVVG 334

  Fly   233 S------------PSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKG 285
            .            ...|..:||..........|:..||:.|...|:..|.  |...:
Mouse   335 QIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNPGTQQNQNAQ--GDKRL-------- 389

  Fly   286 VAGGRCLSPLLIP-----PRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTAPE--SSHAVGR 343
            .|||:.::...:|     ..|....:.....:..:.:|..::..:..|.....|.|  |...:||
Mouse   390 PAGGKAVNTAPVPGQTPHDESDRRTETRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGR 454

  Fly   344 LHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQ 408
            :...|.|::....|||.:::|..|...:..|..||:|::.|.|: ...|.:|.:.|...||::::
Mouse   455 IQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPD-KKHKLETKVKRKNLNPHWNE 518

  Fly   409 HFKFP-VSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDLLRTKKPKED- 471
            .|.|. ...:::..:.|.||||||||:|.||.||||.|.::.:||::....|.||    ||..|
Mouse   519 TFLFEGFPYEKVVQRVLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDL----KPCSDG 579

  Fly   472 ---RPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKRIKKKKTSITKSD 528
               |.|||.||.|.|.|..:.|.|:|||||..:     .:||||::|:...||::|||| :||..
Mouse   580 SGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKT-VTKKR 643

  Fly   529 DPTNPIWNEAFTFNLQSNYLHNAAIEIYVVGAG--SEATEIGCCGLGPQESGTG-CQHWHDMINN 590
            : .|||:||:|.|::.:..|....|.|.|:...  |....||...|. .:||.| .:||.|||..
Mouse   644 N-LNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLS-WKSGPGEVKHWKDMIAR 706

  Fly   591 ARKPTAMWHYIR 602
            .|:|.|.||.::
Mouse   707 PRQPVAQWHQLK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	43/122 (35%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	56/135 (41%)
Syt7	XP_030106854.1	PHA03307	138..>343	CDD:223039	40/208 (19%)
		C2A_Synaptotagmin-7	451..575	CDD:176032	44/128 (34%)
		C2B_Synaptotagmin-7	583..718	CDD:176050	57/137 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820