DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and Syt4

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	132/466 - (28%)
Similarity:	198/466 - (42%)	Gaps:	134/466 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 EPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGVA 287
            :..||....|.|:.:|:.|     |.|.|...    ::|||:        ||..||
  Fly    50 DASFPFQPTRRPTAVRSPS-----GQPPHYLK----KSPSPT--------GGKQMG--------- 88

  Fly   288 GGRCLSPL---LIPPRSQPGV---DPAMGPASPL-----------------GALQPDLYRMP--- 326
               .|||:   ...|.:||.|   :...|||...                 .:|...|:..|
  Fly    89 ---LLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVET 150

  Fly   327 --DGPVYLTAPESS-------------HAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEG--- 373
              :|.|.:|..:.|             ..:|.::.:::|......|.|.:|....| |.:.|
  Fly   151 IANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGL-PCKGGSSG 214

  Fly   374 -------------GFRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQHFKF-PVSRDQLQGKEL 424
                         ...||||:|.|.|: ...|.:|.:.|...||.:|:.|.| .::.:.||...|
  Fly   215 TGDIPTGMNGRTQAATDPYVKLQLLPD-KQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSL 278

  Fly   425 ILQVLDYDRYSHNDIIGEV----------RISVDGLDLSKSVEIWGDLLRTKKPKEDRPELLCSL 479
            ...:|.:||||.:|:||||          .||.:.|.:||.::.....:|.    :.|.|||.||
  Fly   279 HFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRA----QGRGELLISL 339

  Fly   480 NYLPQAERLTVVIMKARNLDT-----LQEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAF 539
            .:.|.|.|||||::|||||..     |.:|||||||:.||:||.||||.:.|.  ..:|::||:|
  Fly   340 CWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKR--TLSPVFNESF 402

  Fly   540 TFNLQS-----NYLHNAAIEIY-----------VVGAGSEATEIGCCGLGPQESGTGCQHWHDMI 588
            .|::.:     ..|...::|:.           |:|    ..|:|    ||..|.|...||:::.
  Fly   403 AFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIG----RLELG----GPNSSSTALNHWNEVC 459

  Fly   589 NNARKPTAMWH 599
            |:.|:..|.||
  Fly   460 NSPRRQIAEWH 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	41/148 (28%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	56/148 (38%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	41/144 (28%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	57/149 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850