Protein Alignment Sytbeta and SYT10

DIOPT Version :10

• Sequence 1: NP_648734.1
• Gene: Sytbeta / 39630
• FlyBaseID: FBgn0261090
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_945343.1
• Gene: SYT10 / 341359
• HGNCID: 19266
• Length: 523
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 148/539 - (27%)
• Similarity: 224/539 - (41%)
• Gaps: 152/539 - (28%)

  Fly    83 PSASSVTSTTSGIGSVSAGSVSDSCDLPTDSEEVAIAKE--------CQPIQPASQLHGMHGGMG 139
            |..|::|:....|.|.           ||:..|....||        .:.|:||.:
Human    88 PVTSNITTLPQSISSA-----------PTEVFETEEKKEIKENEKPAVKAIEPAIK--------- 132

  Fly   140 LNHHHMGTVSATGTDILRGPAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHSGHRG 204
                    :|.|..||   |||| .:.|..|....:   |:||      |.:..::.:|||
Human   133 --------ISHTSPDI---PAEV-QTALKEHLIKHA---RVQR------QITEPTSSTRHS---- 172

  Fly   205 SSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLA 269
                                .|..||   |..|:..|:|...|:
Human   173 --------------------SFRRHL---PRQMQVSSVDFSMGT--------------------- 193

  Fly   270 SLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYLTA 334
                                   .|:|     |.|     ...:.:|.::|:||:..........
Human   194 -----------------------EPVL-----QRG-----ETTTSIGRIKPELYKQKSVDSEGNQ 225

  Fly   335 PESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRKRQTHIHR 399
            .|.....|:|:..::|||....|.|.:|:|.:|...:..|..||||::.|.|: ..:|.||.:||
Human   226 NEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPD-RKKKFQTRVHR 289

  Fly   400 GESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGL----DLSKSVEIWG 460
            ...||.||:.|:|||:.|||..::|...|.|:||:|.:|:||||  .:|.|    |||:...:|.
Human   290 KTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEV--ILDNLFEVSDLSREATVWK 352

  Fly   461 DLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKRIKKK 520
            |:........|..|::.||.|||.|.|:|:.::|.|||..:     .:||||:.|:..|:|:||:
Human   353 DIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKR 417

  Fly   521 KTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYV-----VGAGSEATEIGCCGLGPQESGTG 580
            ||:..|  :..||::|||..|::....:...::.|.|     ||...   .||.|..|....|.|
Human   418 KTTTKK--NTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNE---VIGVCRTGLDAEGLG 477

  Fly   581 CQHWHDMINNARKPTAMWH 599
            ..||::|:...|||...||
Human   478 RDHWNEMLAYHRKPITHWH 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	PHA03307	39..>267	CDD:223039	38/191 (20%)
		C2	341..463	CDD:472691	51/125 (41%)
		C2B_Synaptotagmin	473..601	CDD:175975	49/137 (36%)
SYT10	NP_945343.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	232..356	CDD:176031	51/126 (40%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	49/137 (36%)