DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and Syt14

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_006497318.1	Gene:	Syt14 / 329324	MGIID:	2444490	Length:	857	Species:	Mus musculus

Alignment Length:	699	Identity:	144/699 - (20%)
Similarity:	234/699 - (33%)	Gaps:	192/699 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GASSTAGGNGVSV------------VHILPIGE-----GSTTPPPQPMTPPPS------------ 84
            |:.||:|.|.:||            :|.:|:|.     |:.|....|.....|
Mouse   198 GSLSTSGRNILSVQKCVVTDSSKARMHRVPMGREQEKLGNVTKSKYPSDLEHSDHFEKAKKHNKC 262

  Fly    85 -----------ASSVTSTTSGIGSVSAGSV--SDSCDLP-TDSEEVAIAKECQPIQPASQLHGMH 135
                       ..|...||......:..|:  .|:|..| |:.:.:...|..:.|.| ::.:.:.
Mouse   263 DGLKGNECSGDECSPEDTTRNHRYRAQKSIVKEDTCSAPSTNCKNMFPRKTKEKINP-TKYYKVK 326

  Fly   136 GGMGLNHHHMGTVSATGTDILRGPAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHS 200
            |.|....:...: |..||    ..::|......|..:..|:..|.:  |..||:|..::....|.
Mouse   327 GDMKAKKNEANS-SKRGT----AKSKVGKYSKILPEKDNSYMDRDE--PGSSSESEDEALGKYHE 384

  Fly   201 G----HRGSSPQI------------RTFGP-----DGRSSLPS---------------------- 222
            .    |....|.:            :.:.|     ||.|:..|
Mouse   385 ALSRTHNSRWPLVDSRQKSYAWETRQKYSPLSAEYDGYSTEASMEDGNCIQRMRRTPPLDELQPP 449

  Fly   223 ----EPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAG 283
                :.|.| ||:.:||.:.    ||:|.....|..|.......||:.|....|      .|...
Mouse   450 PYQDDSGSP-HLSCTPSEIG----DAKCEISHCSNSPRCSFNKCPSEGSTGHEA------ESYHN 503

  Fly   284 KGVAGGRCLSPLLIPPRSQPGVDP----AMGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRL 344
            ||....       :|..|...:.|    |.|.:|.|        ..|..|    .||:.:  |.|
Mouse   504 KGYEDD-------VPSDSTAVLSPEDMSAQGSSSQL--------PKPFDP----EPEAKY--GTL 547

  Fly   345 HLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQH 409
            .:...||.....|.|.:....::......|.....|.|:|.| :..::.:|.|.||.. |.|.:.
Mouse   548 DVTFDYDSERQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLP-IKKQRAKTSIQRGPC-PVFTET 610

  Fly   410 FKFPVSRDQLQGKELI-LQVLDYDRYSHNDIIGE-----VRISVDG------------------L 450
            |||.....::.|...: .::....|.....|:||     .::::.|                  .
Mouse   611 FKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDS 675

  Fly   451 DLSKSVEIWGDLLRTKKPKE--DRPELLCSLNYLPQAERLTVVIMKARNLDTL------------ 501
            .:|.|....||...:.:..:  ..||:|..|.|.....||:..::|..:...|
Mouse   676 QVSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCC 740

  Fly   502 ------------QEPYVKIYLIQN-GKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAI 553
                        ::.|||:.|:.: |:.:.|.||| |:...| ||::.|.|.|.:....|.:..:
Mouse   741 LKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCKTS-TRRGQP-NPVYKETFVFQVALFQLSDVTL 803

  Fly   554 EIYVVGAGSEATE--IGCCGLGPQESG-TGCQHWHDMINNARKPTAMWH 599
            .:.|....|...:  ||...||...|| ...:||..|..:..:....||
Mouse   804 ILSVYNRRSMKRKEMIGWISLGLNSSGEEELRHWTAMKESKGQQVCRWH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	30/145 (21%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	39/155 (25%)
Syt14	XP_006497318.1	C2A_Synaptotagmin-14_16	543..666	CDD:176035	26/126 (21%)
Syt14	XP_006497318.1	C2B_Synaptotagmin-14_16	699..855	CDD:176053	39/156 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810