DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and Syt12

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001259513.1	Gene:	Syt12 / 32290	FlyBaseID:	FBgn0261085	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	779	Identity:	185/779 - (23%)
Similarity:	289/779 - (37%)	Gaps:	232/779 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGP-AACWLA-------------HKR-----------IESWSRMAKERVGAVRRV-TLDRNSADE 42
            ||| ||.|:.             ||:           |:|.|.......|:.:|. |:|:...:.
  Fly    27 LGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQSGSEFLLSTSGSFKRFDTIDKEDYNR 91

  Fly    43 GTP---------SGSGASSTAGGN----GVSVVHILPIGEGSTTPPPQPMTPPPSASSVTSTTSG 94
            ...         :|.||.|..|.:    ..:.:..|| ..|...||| |..|.||.:|..:.
  Fly    92 SQQTHQTHLFLMNGGGAVSITGSSSALQATTAMWHLP-RSGIKIPPP-PDRPAPSPNSAAAA--- 151

  Fly    95 IGSVSAGSVSDSCDLPTDSEEVAI----AKECQPIQPASQLHGMHGGMGLNHHHMGTVSATGTDI 155
             |.....|:|...::....|:|..    .:.|     ..|..|..||.|            |..:
  Fly   152 -GKTVTFSLSQVNEVIMPGEQVTSNDQERRSC-----LRQNGGTAGGAG------------GGGV 198

  Fly   156 LRGPAEVFHSPLHLHHQSRSFPPRLQRTPSIS----------SQSSVDSAPSRHSG--------- 201
            |..|.|.  .|          ||||..:.|::          ::..|.:.|:.:||
  Fly   199 LPQPLEA--PP----------PPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVT 251

  Fly   202 -------------HRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARC---GSPA 250
                         .|.||  ...|..:....:||.|......|...|..:|....:.|   .:|.
  Fly   252 PMREGERKAPALKRRNSS--TNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPL 314

  Fly   251 HSADPGDLRTPSPS-----------QSSLAS---------------------------------- 270
            .:.: |.:.|.:||           :.||:|
  Fly   315 ETPN-GPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYL 378

  Fly   271 ---------LAGGSGMGGSSA-----GKGV-AGGRCL----SPLLI------PPRSQPGVDPAMG 310
                     :|.|:|.|..|.     |.|. :.||.|    |.|.:      ...||..:|...|
  Fly   379 FRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAG 443

  Fly   311 --PASPLG-----ALQPDLYRMPDGPVYLTAPESSHA--VGRLHLRVKYDY-----HLFDLTVHL 361
              |.|..|     |:..|.. ..|..::|...:..:.  .|.|.:.:.||.     ...:|||.:
  Fly   444 SVPGSMDGINLERAISCDSV-TSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSV 507

  Fly   362 IEAHNL-SPIEEGGFRDPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELI 425
            :||..| .|...... |.:||:.|.|: .....||.:.:|...|.:::.|.|.:.:.|.:
  Fly   508 LEAKGLICPFSVESL-DTFVRIYLVPD-HPGAMQTKVVKGTLTPSYNESFDFWLHKRQAR----- 565

  Fly   426 LQVLDYDRYSHN----DIIGEVRISVDGLDLSKSVEIWGDLLRTKKPKEDRPELLCSLNYLPQAE 486
             ..|.:..| ||    .:|||..:.:.  ::.:.:..|..|..::|......||:.||:|||.||
  Fly   566 -HSLWFHLY-HNGPAHTLIGEAEMEIG--EMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAE 626

  Fly   487 RLTVVIMKARNL------------DTLQEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAF 539
            |||:|::|||||            :|:...:||:||:...:::.||:||:.:.|  .:||:||:.
  Fly   627 RLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKD--RSPIFNESM 689

  Fly   540 TFNLQSNYLHNAAIEIYVVG-AGSEATEIGCCGLGPQESGTGCQHWHDMINNARKPTAMWHYIR 602
            .|::....|....:.:.|.| ..|..|.:|....|....|.|.:|||.|:::.|||.||||.:|
  Fly   690 IFSVPPPSLTTTQLRVTVFGVTTSGVTPLGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVLR 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	31/131 (24%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	53/140 (38%)
Syt12	NP_001259513.1	C2	503..602	CDD:278593	27/109 (25%)
Syt12	NP_001259513.1	C2B_Synaptotagmin-12	612..753	CDD:176051	53/142 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850