DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Syt3

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_061995.1	Gene:	Syt3 / 25731	RGDID:	3805	Length:	588	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	161/541 - (29%)
Similarity:	227/541 - (41%)	Gaps:	140/541 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IQPASQLHGMHGGMGLNHHHMGTVSATGTDILRGPAEVFHSPLH-LHHQ-----------SRSFP 177
            :.|...|.|:.||.|   ||:| .|..|..:|.||    |...| .||.           ..|.|
  Rat   101 LAPGVGLAGLVGGGG---HHLG-ASLGGHPLLGGP----HHHAHPAHHPPFAELLEPGGLGGSEP 157

  Fly   178 PRLQRTPSISSQSSVDSA-----------PSRHSGHRGSSPQIRTFGPDGRSSL---PSEPGFP- 227
            |.    ||.....|...|           ||:      :||::.:.|..|...|   ||..|.|
  Rat   158 PE----PSYLDMDSYPEAAVASVVAAGVKPSQ------TSPELPSEGGTGSGLLLLPPSGGGLPS 212

  Fly   228 ---HHLARS----------PSPM--RTISLDARCGSPAHSADPGDLRTPSPSQSSLASLAG---- 273
               |....|          |.|:  :|::..|   .|:....|..|..|.|.....|.|.|
  Rat   213 AQSHQQVTSLAPTTRYPALPRPLTQQTLTTQA---DPSSEERPPALPLPLPGGEEKAKLIGQIKP 274

  Fly   274 ----GSGMGG--SSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPDGPVYL 332
                |:|.||  :..|.|.||..|
  Rat   275 ELYQGTGPGGRRTGGGSGEAGAPC----------------------------------------- 298

  Fly   333 TAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRKRQTHI 397
                     ||:...::|.|....|.|.:::|.:|...:..||.||||::.|.|: ..:|.||.:
  Rat   299 ---------GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD-RKKKFQTKV 353

  Fly   398 HRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSV---EIW 459
            ||...||.|::.|:|.|...:|..::|...|.|:||:|.:|:||:|.:. :.|:|::..   .:|
  Rat   354 HRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLD-NLLELAEQPPDRPLW 417

  Fly   460 GDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKRIKK 519
            .|:|.....|.|..||..||.|||.|..|||.|:||.||..:     .:||||..||..|:|:||
  Rat   418 RDILEGGSEKADLGELNFSLCYLPTAGLLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKK 482

  Fly   520 KKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEIYVVG---AGSEATEIGCCGLGPQESGT-G 580
            :||||.|  :..||.:|||..|::....:.|..:.|.||.   .|.... ||.|.:||:.:.. |
  Rat   483 RKTSIKK--NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEV-IGVCRVGPEAADPHG 544

  Fly   581 CQHWHDMINNARKPTAMWHYI 601
            .:||.:|:.|.|||...||.:
  Rat   545 REHWAEMLANPRKPVEHWHQL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	42/124 (34%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	57/136 (42%)
Syt3	NP_061995.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	10..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..161		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..222		12/44 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..257		5/21 (24%)
		C2A_Synaptotagmin-1-5-6-9-10	297..422	CDD:176031	43/176 (24%)
		C2B_Synaptotagmin-3-5-6-9-10	431..565	CDD:176048	57/136 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780