DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and PLA2G4F

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_998765.3	Gene:	PLA2G4F / 255189	HGNCID:	27396	Length:	849	Species:	Homo sapiens

Alignment Length:	274	Identity:	63/274 - (22%)
Similarity:	107/274 - (39%)	Gaps:	62/274 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 GPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFRDPYVRLMLQPEVDSRK 392
            |.|.|...|....:.|...|..|.|  :||.|.::.|.|:...:.....|.||:|.| |......
Human    19 GAVLLQKREKRGPLWRHWRRETYPY--YDLQVKVLRATNIRGTDLLSKADCYVQLWL-PTASPSP 80

  Fly   393 RQTHIHRGESNPYFDQHFKFPVSRDQLQGK-ELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSV 456
            .||.|....|:|.:::.|.:     |:.|. :.:|::..||:    ||:|..::|:...||..
Human    81 AQTRIVANCSDPEWNETFHY-----QIHGAVKNVLELTLYDK----DILGSDQLSLLLFDLRS-- 134

  Fly   457 EIWGDLLRTKKP------------KEDRPELLCSLNYLPQAERLTVVIMKA----RNLDTL---- 501
                  |:..:|            :|.:.|.:...:.:|.:|.:|..::.|    |...||
Human   135 ------LKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITNGVLVAHPCLRIQGTLRGDG 193

  Fly   502 ---QEPYVKIYLIQNGKRIKK-------KKTSITKSDDPTNPIWNEAFTFNLQ---SNYLHNAAI 553
               :|.|        |.|..:       :|..:.....||.|.....|||::.   |:.||...:
Human   194 TAPREEY--------GSRQLQLAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPVLSSRLHVELM 250

  Fly   554 EIYVVGAGSEATEI 567
            |:........:.|:
Human   251 ELLAAVQSGPSAEL 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	32/122 (26%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	24/116 (21%)
PLA2G4F	NP_998765.3	C2_cPLA2	46..163	CDD:176001	31/134 (23%)
		PLAc	295..791	CDD:214474
		cPLA2_Grp-IVB-IVD-IVE-IVF	303..845	CDD:132840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900