DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytbeta and Sytl5

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_808372.1	Gene:	Sytl5 / 236643	MGIID:	2668451	Length:	753	Species:	Mus musculus

Alignment Length:	638	Identity:	144/638 - (22%)
Similarity:	226/638 - (35%)	Gaps:	198/638 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KERVGAVRRVTLDRNSADEGTPSGSGASSTAGGNGVSVVHILPIGEGSTTPPPQPMTPPPSASSV 88
            |...|:.|..|...:..|:.....:..||.:.|.       :|:.:.|         |.|||.||
Mouse   223 KSASGSDRGSTTSSDLIDQEAGRRTSKSSYSNGG-------IPVTQRS---------PVPSAHSV 271

  Fly    89 TSTTS---GI-GSVSAGSVSDSCDLPTDSEEVAIAKECQPIQPASQLHGMHGGMGLNHHHMGT-- 147
            ||..|   |. .|::..::.::|:..|.|.                          ..:..||
Mouse   272 TSINSREHGFENSMALATIENTCEELTKSH--------------------------RRNTSGTPS 310

  Fly   148 VSATGTDILRGPAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHSGHRGSSPQIRTF 212
            ::.:||.:   .:|...|.:.|   |.||...|:.|.||.|:
Mouse   311 IAVSGTSL---SSERSRSEVDL---SESFAEDLEDTSSIRSR----------------------- 346

  Fly   213 GPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCGSPAHSADPGDLRTP--SPSQSSLASLAGGS 275
                     |.||               :||....|...:.|..||.:.  |.:..||||....:
Mouse   347 ---------SVPG---------------ALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGLSTN 387

  Fly   276 GMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPASPLGALQPDLYRMPD-GPVYLTAPESSH 339
            ...||..                .||...|..|....:.|.::........| |.|.:|
Mouse   388 SQAGSDR----------------KRSYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVT------ 430

  Fly   340 AVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFR-DPYVRLMLQPEVD-SRKRQTHIHRGES 402
              |.:.|.:.|.|....|.:.:....||:..:|...| |.||:..|.|:.. :.||:|.|..| :
Mouse   431 --GEILLHISYCYKTGGLYIFVKSCRNLATGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTG-T 492

  Fly   403 NPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDLLRTKK 467
            ||.|::..|:.:|..||:.:.|.|.|..|||:..|..:|||.|:.|..:.....:.|..|    :
Mouse   493 NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPCDEWFVL----Q 553

  Fly   468 PKED---------RPELLCSLNYLPQAER-----------------------------LTVVIMK 494
            ||.:         :.||...|.|:|..|.                             |.|.|.|
Mouse   554 PKVELAPDISLQYKGELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKESSSISGGILEVFIKK 618

  Fly   495 ARNLDTLQ-----EPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFN-LQSNYLHNAAI 553
            |:||..::     :.:||.||:.:..:..|.||::.|..  .||.||..|.|: |....:.||.:
Mouse   619 AKNLTAVKSGGTSDSFVKGYLLPDDNKATKHKTAVVKKS--VNPEWNHTFIFSGLYPQDIKNACL 681

  Fly   554 EIYVVGAGSEATEIGCCGLGPQESGTGCQH----------------WHDMINN 590
            |:.:....:.::.:...|: ...||:|..:                |..|.:|
Mouse   682 ELTIWDKEAFSSNVFLGGV-RLNSGSGMSYGKTVDWMDSHGEEQRLWQKMADN 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	39/123 (32%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	38/169 (22%)
Sytl5	NP_808372.1	PHD_SF	11..123	CDD:419867
		FYVE_Slp5	62..108	CDD:277305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..279		19/71 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..359		22/140 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..404		8/39 (21%)
		C2A_SLP-4_5	430..553	CDD:175995	41/135 (30%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	38/170 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900