DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Rph3a

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_011246487.1	Gene:	Rph3a / 19894	MGIID:	102788	Length:	684	Species:	Mus musculus

Alignment Length:	545	Identity:	133/545 - (24%)
Similarity:	214/545 - (39%)	Gaps:	111/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 TGTDILRG-PAEVFHSPLHLHHQSRSFPPRLQRTPSISSQSSVDSAPSRHSGHRGSSPQIRTFGP 214
            :|....:| |.:|...|:.:   .::.|.:....|:...|.:.:|.....:..||.....|..|.
Mouse   150 SGAWFFKGFPKQVLPQPMPI---KKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQ 211

  Fly   215 DGRSSLPSEPGFPHH----LARSPSPMRTISLDARCGSPAHSADPGDL-RTPS------------ 262
            .....|.|.||...|    ...|.:.|.|.:.|:.....||....||. |:|:
Mouse   212 KPGPDLTSAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAGEQGLRRANSVQ 276

  Fly   263 ---PSQSSLASLAGGSGM-----GGSSAGKGVAGGRCLSPLLIPPRSQPGVDPAMGPA-----SP 314
               |:.:.:.|.|....:     |||.|..|  .||........|.|.||...|:.||     .|
Mouse   277 AARPAPAPVPSPAPPQPVQPGPPGGSRATPG--PGRFPEQSTEAPPSDPGYPGAVAPAREERTGP 339

  Fly   315 LGALQPDLYRMPDGPVYLTAP-------------------ESSHAVGRLHLRVKYDYHLFDLTVH 360
            .|..|...:..  .|....||                   :.:..:|.|...:.||....:|...
Mouse   340 AGGFQAAPHTA--APYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCT 402

  Fly   361 LIEAHNLSPIEEGGFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFKF-PVSRDQLQGKE 423
            :|.|..|.|::..|..||||:|.|.|... |.|.:|...|...||.:::..:: .::.:.:|.|.
Mouse   403 IIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKT 467

  Fly   424 LILQVLDYDRYSHNDIIGEVRISVDGLDLS--------------------------------KSV 456
            |.:.|.|.|::.||:.|||.|.|:..|..:                                :.|
Mouse   468 LRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQV 532

  Fly   457 EIWGDLLRTKKPKEDRPELLCSLNYLPQAERLTVVIMKARNLDTL-----QEPYVKIYLIQNGKR 516
            |..||:       |:|.::|.||.|..|...|.|.|::..:|..:     .:|:||::|..:..:
Mouse   533 ERIGDI-------EERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGK 590

  Fly   517 IKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNAAIEI----YVVGAGSEATEIGCCGLGPQES 577
            ..|.||.|.|.  ..||.:||.|.::::.:.|...:::|    |.:|..::  .||.|.||....
Mouse   591 KAKHKTQIKKK--TLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSND--YIGGCQLGISAK 651

  Fly   578 GTGCQHWHDMINNARKPTAMWHYIR 602
            |...:||::.:.|..|....||.::
Mouse   652 GERLKHWYECLKNKDKKIERWHQLQ 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	41/155 (26%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	39/136 (29%)
Rph3a	XP_011246487.1	FYVE_RP3A	88..168	CDD:277301	5/17 (29%)
		PRK07764	<175..352	CDD:236090	42/180 (23%)
		C2A_Rabphilin_Doc2	383..506	CDD:176000	37/122 (30%)
		C2B_Rabphilin_Doc2	543..675	CDD:176030	39/135 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910