DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytbeta and Syt17

DIOPT Version :9

Sequence 1:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_620204.1	Gene:	Syt17 / 192189	RGDID:	708576	Length:	474	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	133/458 - (29%)
Similarity:	201/458 - (43%)	Gaps:	83/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 FPPRLQRTPSISSQSSVDSAPSRHSGHRGSSPQI--RTFGPDGRSSLPSEPGFPHHLARSPSPMR 238
            ||  .|..|.:.:..|.|.  ...|.|..|...:  ||..||||.|            .|.:...
  Rat    53 FP--AQTPPWLMASRSNDK--DGDSVHTASDVPLTPRTNSPDGRRS------------SSDTSKS 101

  Fly   239 TISLDARCGSPAHSADPGDLRTPSPSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQP 303
            |.||..|..|.       |.|.||.....:..:..|                     ::..:.:|
  Rat   102 TYSLTRRISSL-------DSRRPSSPLIDIKPIEFG---------------------VLSAKKEP 138

  Fly   304 GVDPAM-----GPASPLGALQPDLYRMP---DGPVYLTAPE--SSHAVGRLHLRVKYDYHLFDLT 358
             :.|::     .|.......:|.||.:.   |....||..|  |.:.:|.||...:||.....||
  Rat   139 -IQPSVLRRTYTPDDYFRKFEPRLYSLDSNLDDVDSLTDEEIMSKYQLGMLHFSTQYDLLHNHLT 202

  Fly   359 VHLIEAHNL-SPIEEGGFR------DPYVRLMLQPEVDSRKRQTHIHRGESNPYFDQHFKFPVSR 416
            |.:|||.:| .||...|.|      :|||::.|.|: ....:||.:.|....|.|::.:.|.:..
  Rat   203 VRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPD-QKNSKQTGVKRKTQKPVFEERYTFEIPF 266

  Fly   417 DQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDLSKSVEIWGDLLRTKKPKEDRPELLCSLNY 481
            .:.|.:.|:|.|:|:|::|.:.:||:|.:.:..:||.|....|..|:.:.:.:.:..|||.||||
  Rat   267 LEAQRRTLLLTVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNY 331

  Fly   482 LPQAERLTVVIMKARNL---DTLQ--EPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTF 541
            ||.|.||.|.|::|:.|   |..|  :|:|||.|:...|.:|.||||..:.  ..:|.:||:|:|
  Rat   332 LPSAGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRG--TIDPFYNESFSF 394

  Fly   542 NLQSNYLHNAAIEIYVVGAGSEATE-------IGCCGLGPQESGTGCQHWHDMINNARKPTAMWH 599
            .:....|.||::...|.|...:::.       ||....||.||    .||..|:|..|.....||
  Rat   395 KVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSES----NHWRRMLNTHRTAVEQWH 455

  Fly   600 YIR 602
            .:|
  Rat   456 SLR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	41/128 (32%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	52/139 (37%)
Syt17	NP_620204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117		20/77 (26%)
		C2A_Synaptotagmin-15-17	186..314	CDD:176036	42/128 (33%)
		C2B_Synaptotagmin-17	323..457	CDD:176055	52/139 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820