Protein Alignment Sytbeta and Doc2b

DIOPT Version :10

• Sequence 1: NP_648734.1
• Gene: Sytbeta / 39630
• FlyBaseID: FBgn0261090
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_031899.2
• Gene: Doc2b / 13447
• MGIID: 1100497
• Length: 412
• Species: Mus musculus
• Alignment Length: 442
• Identity: 121/442 - (27%)
• Similarity: 179/442 - (40%)
• Gaps: 78/442 - (17%)

  Fly   183 TPSISSQSSVDSAPSRHSGHRGSSPQIRTFGPDGRSSLPSEPGFPHHLARSPSPMRTISLDARCG 247
            |.||....::|..|    |......||..:.|.....||     |....|:|:|.     ||...
Mouse    11 TISIQEHMAIDVCP----GPIRPIKQISDYFPRFPRGLP-----PTAAPRAPAPP-----DAPAR 61

  Fly   248 SPAHSADPGDLRTPS----PSQSSLASLAGGSGMGGSSAGKGVAGGRCLSPLLIPPRSQPGVDPA 308
            |||.||.|   |:||    .....:..|.|..|..                    |...||..||
Mouse    62 SPAASASP---RSPSDGARDDDEDVDQLFGAYGAS--------------------PGPSPGPSPA 103

  Fly   309 MGPASPLGALQPDLYRMPDGPVYLTAPESSHAVGRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEG 373
            ..||.| ...:||:    ||    ...:...|:|.|...:.||.....|...:.:|..|.|::..
Mouse   104 RPPAKP-PEDEPDV----DG----YESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHN 159

  Fly   374 GFRDPYVRLMLQPEVD-SRKRQTHIHRGESNPYFDQHFK-FPVSRDQLQGKELILQVLDYDRYSH 436
            |..||||:|.|.|... :.|.:|...|...||.:::... :.::.:.:..|.|.:.|.|.|::.|
Mouse   160 GLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMVRKTLRISVCDEDKFRH 224

  Fly   437 NDIIGEVRISVDGLD----------LSKSVEIWGDLLRTKKPKEDRPELLCSLNYLPQAERLTVV 491
            |:.|||.|:.:..|.          |.|.:.:  |....|. .|:|..:|.||.|..|.:.|.|.
Mouse   225 NEFIGETRVPLKKLKPNHTKTFSICLEKQLPV--DKAEDKS-LEERGRILISLKYSSQKQGLLVG 286

  Fly   492 IMKARNLDTL-----QEPYVKIYLIQNGKRIKKKKTSITKSDDPTNPIWNEAFTFNLQSNYLHNA 551
            |::..:|..:     .:||||.||..:..:..|.||::.|.  ..||.:||.|.:.::...|...
Mouse   287 IVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKK--TLNPEFNEEFCYEIKHGDLAKK 349

  Fly   552 AIEI----YVVGAGSEATEIGCCGLGPQESGTGCQHWHDMINNARKPTAMWH 599
            .:|:    |.:|..::.  ||...||....|...:||.|.:.|..|....||
Mouse   350 TLEVTVWDYDIGKSNDF--IGGVVLGINAKGERLKHWFDCLKNKDKRIERWH 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytbeta	NP_648734.1	PHA03307	39..>267	CDD:223039	26/87 (30%)
		C2	341..463	CDD:472691	36/133 (27%)
		C2B_Synaptotagmin	473..601	CDD:175975	40/136 (29%)
Doc2b	NP_031899.2	Mediates interaction with DYNLT1. /evidence=ECO:0000250	1..90		28/95 (29%)
		Negatively regulates targeting to plasma membrane	1..36		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..123		33/126 (26%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	33/122 (27%)
		Mediates interaction with STXBP3. /evidence=ECO:0000269|PubMed:17548353	257..375		36/122 (30%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	40/135 (30%)